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21 Cards in this Set
- Front
- Back
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Describe the genome and structure of papilloma and polyoma viruses
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They are both dsDNA with a naked icosohedral capsule
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How are papilloma viruses transmitted?
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They are transmitted by contact with cutaneous/mucosal lesions
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How are polyoma viruses transmitted?
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They are transmitted by exposure to infected respiratory secretions and urine
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What does the infection with papilloma cause?
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Persistant cutaneous or mucosal lesions (warts)
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What disease is associated with the JC polyoma virus?
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It causes progressive multifocal leukoencephalopathy, a fatal encephalitis and demyelinating disease of the immunocompromised
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What polyoma virus causes Merkel cell carcinoma?
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Merkel cell polyomavirus
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Common warts (verrucae vulgaris) are associated with which virus (be specific)?
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human papilloma virus 2,4, and 7
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What type of wart is caused by HPV-1?
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Plantar warts (verrucae plantaris)
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Verrucae plana (flat arts) are assoicated with what viruses?
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human papilloma 3 and 10
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What are the most common types of virus causing anogenital warts (condyloma acuminata)?
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HPV 6 and 11
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Which viruses are the cause of most cervical cancer?
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HPV 16 and 18
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Human papilloma virus 6 and 11 can cause what sort of lesions?
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Anogenital warts as well as warts developing in the mouth and throat and can be transmitted to newborns from a mother with infected lesions; these can cause recurrent respiratory papillomatosis
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What is recurrent respiratory papillomatosis?
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A chronic disease caused by HPV 6 and 11 with laryngeal papillomas that cause airway obstruction
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Describe the vaccine given to females for HPV
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It is a recombinant "virus like particle" assembled in cells expressing the L1 capsid protein of HPV, making empty icosohedral capsids which are immunogenic and protective
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When is the HPV vaccine given?
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!st dose at 11-12yo, 2nd and 3rd dose 2 and 6 months later
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What are adeno-associated viruses?
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Parvoviruses in the genus Dependo which require co-infection with adenovirus for replication
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What clinical syndromes are associated with erythrovirus B19 (parvo B19)?
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It is the cause of erythema infectiosum (5th disease), hypoplastic crisis in sickle-cell patients, aplastic crisis in patients with hereditary spherocytosis, and fetal death/hydrops in pregnant females
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What is different about erythrovirus B19 compared to other parvoviruses?
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It does not require adenovirus co-infection
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Describe the transmission of erythrovirus B19 and the duration of immunity
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It is transmitted mainly by respiratory secretions and has an acquired life-long immunity
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Describe the primary infection of adults
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It may lead to arthritis and arthralgia with or without rash
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Explain the pathogenesis of the erythovirus
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It has cytocidal replication within erythroid precursers; it only infects eryroid cells due to the blood group P glycolipid antigen
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