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35 Cards in this Set
- Front
- Back
carbamazepine |
Na channel blocker For treating seizures |
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phenytoin |
Na channel blocker For treating seizures |
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topiramate |
Na channel blocker For treating seizures |
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zonisamide |
Na channel blocker For treating seizures |
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lamotrigine |
Na channel blocker For treating seizures |
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valproate |
Na and Ca channel blocker For treating seizures |
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ethosuximide |
Ca channel blocker For treating seizures |
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benzos/barbs |
GABAa recep agonist |
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tiagabine |
prolongs presence of GABA in synapse |
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vigabatrin |
inhibits degradation of GABA |
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L-dopa |
drug that restores DA in brain |
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carbidopa |
drug that inhibits L-dopa metabolism in periphery, increasing its CNS levels |
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pramipexole/ropinirole |
DA agonists for treatment of PD |
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benztropine/trihexyphenidyl |
anti-ACh drugs for treatment of PD |
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selegiline/rasagiline |
selective MAO-B inhibitor (MAO-B degrades DA in striatum) for treatment of PD |
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entacapone |
COMT inhibitor (COMT degrades DA) acts in periphery only for treatment of PD |
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tolcapone |
COMT inhibitor (COMT degrades DA) acts centrally and peripherally for treatment of PD |
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amantadine |
NMDA inhibitor treatment of L-dopa-induced dyskinesia |
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MPTP |
drug byproduct that induces PD |
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donepezil |
AChE inhibitor when combined with memantine, shown to have greater benefit for treatment of AD tx often fails b/c of systemic side fx, untreatable tissue atrophy, and because AD is very complex |
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rivastigmine/galantamine |
AChE inhibitor for treatment of AD tx often fails b/c of systemic side fx, untreatable tissue atrophy, and because AD is very complex |
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tacrine |
AChE inhibitor for treatment of AD rarely used d/t adverse side fx tx often fails b/c of systemic side fx, untreatable tissue atrophy, and because AD is very complex |
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memantine |
noncompetitive NMDAR antags; acts on Mg to prevent excitotoxicity when combined with donepezil, shown to have greater benefit |
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atypical antipsychs/mood stabilizers/antideps |
used to treat behavioral symps of AD |
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riluzole |
only approved tx for ALS unknown MOA, but fx include glutamate inhibits, NMDA/kainate inhib, Na inhib |
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baclofen |
GABAb agonist for treating ALS spasticity (ALS causes loss of upper motor neurons, which means loss of GABA) |
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diazepam |
GABAa agonist for treating ALS spasticity (ALS causes loss of upper motor neurons, which means loss of GABA) |
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amitriptyline |
TCA anti-ACh drug to prevent excessive saliva production in ALS |
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acamprosate |
helps prevent alcoholic relapse MOA: modulates changes in glutamatergic & GABAergic activity associated w/ EtOH use doesn't prevent withdrawal |
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naltrexone |
opioid antagonist (opioids are involved in reinforcement pathways) can block dependency fx of morphine when co-adm |
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disulfiram |
ALDH inhibitor increases acetaldehyde levels (can cause toxicity) poor compliance and potential DDIs w/ EtOH-containing OTCs |
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clonidine |
a2 agonist effective at reducing CNS hyperactivity associated w/ acute opioid withdrawal |
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naloxone |
drug for reversing opioid ODs |
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amphetamine |
directly acting drug that has highest increase of DA release MOA: causes dumping of DA in synapse through DAT uptake |
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cocaine |
directly acting drug that has a high increase of DA release MOA: inhibits DAT, which is responsible for uptake of DA in synapse |