Platelet Structure. Hemostasis And Coagulation. Week 9

Front 1

Fibrinolysis

Back 1

Process of digestion and removal of fibrin clot
Steps involved
Tissue Plasminogen activator
Fibrin degradation products

Front 2

eiconosoid platelet inhibitor

Back 2

prostacyclin

Front 3

vascular relaxing factor

Back 3

nitric oxide

Front 4

anticoagulant glucosaminoglycan

Back 4

heperan sulfate

Front 5

coagulation extrinsic pathway regulator

Back 5

tissue factor pathway inhibitor

Front 6

a protein C coagulation control system activator, maintains cell membrane

Back 6

thrombomodulin

Front 7

structural features of vascular intima in hemostasis

Back 7

endothelial cells, internal elastic lamina, fibroblasts, smooth muscle cells

Front 8

procoagulant properties of the damaged vascular intima: smooth muscle cells in arterioles and arteries

Back 8

induce vasoconstriction

Front 9

procoagulant properties of the damaged vascular intima: damaged subendothelial collagen

Back 9

binds VWF and platelets, secretes adhesion molecules- P selectins, I-CAMs, P-CAMs

Front 10

procoagulant properties of the damaged vascular intima: exposed muscle cells and fibroblasts

Back 10

tissue factor exposed on cell membrane

Front 11

procoagulant properties of the damaged vascular intima: endothelial cells in inflammation

Back 11

tissue factor is induced by inflammation

Front 12

Fibrinolytic properties of Endothelial Cells

Back 12

Secrete TPA

Plasminogen activator inhibitor (PAI-1) control protein
Thrombin-activatable fibrinolysis inhibitor (TAFI)

Front 13

platelet adhesion disease

Back 13

reversible. Bernard Soulier and von Willebrand

Front 14

platelet aggregation disease

Back 14

irreversible. afibrinogenemia and Glanzman thromboasthenia

Front 15

platelet secretion disease

Back 15

irreversible

Front 16

Platelet granular content- Large

Back 16

beta- thromboglobulin

Factor V

Factor XI

Protein S

Fibrinogen

Von Willebrand factor

Platelet Factor 4 (heparin inhibitor)

Platelet derived growth factor

Front 17

Platelet granular contents- Small molecules

Back 17

adenosine diphosphate (activates neighboring platelets). adenosine triphosphate. calcium. serotonin (vasoconstrictor)

Front 18

In arterioles and arteries where blood moves rapidly, platelets adhere by binding

Back 18

von Willebrand Factor

Front 19

How does aspirin impair platelet function?

Back 19

It impairs cyclooxygenase-1 and TXA2 synthesis

Front 20

Other blood cells involved in hemostasis

Back 20

Erythrocytes: Provide bulk and structural integrity. Monocytes and lymphocytes: Provide TF that triggers coagulation. Leukocytes: Membrane integrins and selectins

Front 21

Factor I

Back 21

Fibrinogen- Thrombin substrate, polymerizes to form fibrin

Front 22

Factor II

Back 22

Prothrombin- Serine proteases

Front 23

Factor III

Back 23

Tissue factor- Cofactor

Front 24

Factor IV

Back 24

Ionic Calcium- Mineral

Front 25

Factor V

Back 25

Labile factor- cofactor

Front 26

Factor VII

Back 26

Stable factor- Serine protease

Front 27

Factor VIII

Back 27

Antihemophilic factor- Cofactor

Front 28

VWF

Back 28

von Wilderbrand Factor- Factor VIII carrier and platelet and adhesion

Front 29

Factor IX

Back 29

Christmas Factor- Serine proteases

Front 30

Factor X

Back 30

Stuart Prower- Serine protease

Front 31

Factor XI

Back 31

Plasma thromboplastin antecedant PTA- serine protease

Front 32

Factor XII

Back 32

Hageman factor- serine protease

Front 33

Prekallikrein

Back 33

Fletcher factor, pre-K

Front 34

High molecular weight kininogen

Back 34

Fitzgerald factor, HMWK- cofactor

Front 35

Factor XIII

Back 35

Fibrin Stabilizing Factor (FSF) Trasglutaminase, transamidase

Front 36

Platelet Factor 3

Back 36

phospholipids, phosphatidylserine, PF3. Assembly molecule

Front 37

where is fibrinogen synthesized?

Back 37

the liver

Front 38

What are the hemorhagic levels of Factor VIII?

Back 38

?

Front 39

Extrinsic Pathway

Back 39

Tissue Factor Pathway

Front 40

Present on vascular cells not normally in contact with blood e.g. fibroblasts

Back 40

Tissue factor

Front 41

Tissue Factor TF

Back 41

–membrane receptor for factor VIIa

Front 42

Deficiencies of XII, HMWK, or pre-K

Back 42

do not cause bleeding problems

Front 43

Deficiencies in factor XI

Back 43

lead to mild bleeding disorders

Front 44

Composition of contact factor complex

Back 44

Factor XIIa
HMWK (Fitzgrald)
Pre-K (fletcher)

Front 45

chief protease of the coagulation pathway

Back 45

THROMBIN

Front 46

Primary function – cleave fibrinopeptides A and B from α and ß chains of fibrinogen molecule triggering fibrin polymerization
Amplifies coagulation mechanism by activation cofactors V and VII and factor XI
Activates XIII, fibrin stabilizing factor
Initiates aggregation of platelets

Back 46

thrombin

Front 47

activates protein C pathway to suppress coagulation and activates Thrombin-activatable fibrinolysis inhitor (TAFI)

Back 47

Thromobin bound to thrombomodulin

Front 48

pathway that begins with factor XII and ends with fibrin polymerization

Back 48

intrinsic pathway

Front 49

Laboratory test monitoring intrinsic pathway

Back 49

aPPT

Front 50

Tissue factor pathway factor VII, X, V, prothrombin, and fibrinogen

Back 50

extrinsic pathway

Front 51

Laboratory test to monitor extrinsic pathway

Back 51

PT

Front 52

Factor X and factor V, prothrombin, and fibrinogen

Back 52

common pathway

Front 53

cell based coagulation

Back 53

TF pathway

Front 54

cell based coagulation

Back 54

Platelets and VIII:VWF come in extravascular space
Platelets activated by thrombin and adherence to collagen
COAT platelets
Factor V activated by thrombin
Factor VII activated and dissociated from VWF
Factoe XI activated

Front 55

Occurs on surface of platelets
Factor IXa binds to VIIia on platelet
IXa:VIIIa activates Xa
Xa binds to Va activates prothrombin and generates thrombin
Thrombin cleaves fibrinogen and activates factor XIII which stabilizes clot
Activates factor XIII
Binds to thrombomodulin to activate protein C control pathway and TAFI
Deficiency of VII, IX, VIII, X,V or II cause severe bleeding

Back 55

cell based coagulation

Front 56

Factor inhibited – inactivates Xa
Binds to TF:VIIa to prevent Xa activation
Protein S

Back 56

Tissue Factor Pathway Inhibitor

Front 57

Antithrombin
Heparin cofactor II
α1-Antitrypsin
α2-Macroglobulin
Protein Zdependent protease inhibitor

Back 57

Serine protease inhibitors

Front 58

What are the four major systems involved with hemostasis?

Back 58

?

Front 59

What are the procoagulant properties of the vascular intima?

Back 59

?

Front 60

What are the three processes of platelets?

Back 60

?

Front 61

What are the three complexes in coagulation and the factors included in each?

Back 61

?

Front 62

Describe the role the fibrinolytic system plays in hemostasis.

Back 62

?