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22 Cards in this Set
- Front
- Back
- 3rd side (hint)
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History
Three major pandemics of plague |
Sixth century A.D. – Middle East and Mediterranean
Eighth-fourteenth centuries 1855 to present – China and beyond |
__ century A.D.
__-___ centuries 1855 to ______ |
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Epidemiology
Males > females? old > young? |
no age or sex preference
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Epidemiology
Worldwide? in US? |
1600 cases per year worldwide during last 40 years
10-15 cases per year in US during last few decades |
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Epidemiology
has killed? |
has killed 200m
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Etiology
Causative agent |
Yersinia pestis
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Y____nia p_____
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Etiology
Three forms: |
Bubonic
Pneumonic Septicemic |
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Etiology
Bubonic |
large dark buboes develop on skin where underlying necrotic lymph
tissue exists |
nasty looking
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Etiology
Pneumonic |
respiratory form, fever, chills, cough, chest pain, may have buboes
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___________ form, fever, chills, ______, chest ____, may have _______
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Etiology
Septicemic |
bacteria in blood, nausea, emesis, diarrhea, rapid decline of patient
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bacteria in ______,_______, emesis, diarrhea, rapid _______ of patient
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Transmission
Bubonic |
by bite of flea usually (75-97% of cases)
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vector
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Transmission
Pneumonic |
inhalation of respiratory droplets carrying bacteria 14%
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vector
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Transmission
Septicemic |
destiny of other forms; any means of infecting blood <20%
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Vector
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Pathogenesis
Bubonic step 1 |
vector = flea bite
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Pathogenesis
Bubonic step 2 |
vesicle develops at site of bite, grows
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_______ develops at site of bite, grows
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Pathogenesis
Bubonic Step 3 |
bacteria infect lymph nodes in area of bite, forming buboes
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form buboes by infecting _____ _______
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Pathogenesis
Bubonic step 4 |
Buboes may rupture; bacteria infect blood
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buboes _______
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Pathogenesis
Pneumonic infection of Yersinia Pestis (step 1) |
respiratory
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Pathogenesis
Pneumonic Step 2 |
First signs/symptoms
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Pathogenesis
Pneumonic step 3 |
Within 2-4 days, respiratory failure, death
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pathogenesis
Septicemic: |
blood infection by yersinia pestis
Can progress to brain and other organs; fatal without quick antibiotic treatment |
can progress to...
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Treatment/Prophylaxis
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Vaccine is available for military or aid workers; quarantine used worldwide for plague
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Treatment/Prophylaxis
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Rx: Streptomycin or gentamycin; more effective if given early
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strept__ycin or gent__ycin
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