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12 Cards in this Set
- Front
- Back
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Why study metabolite kinetics? |
Some can be toxic, some therapeutic, some inhibit metabolism of another drug or parent drug, some displace other drug/parent drug from binding site |
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Formation rate limited when? |
Ke < km/4, will see parallel slopes |
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Formation rate limited: Ke is small, so there isn't much metabolite ever in the body because it is formed relatively ______ and eliminated _____. |
slowly, rapidly |
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Elimination Rate limited when? |
Ke > 4km, see intersection of two curves |
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Elimination rate limited: metabolite gets formed ____ and eliminated ______
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quickly, slowly |
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Elimination rate limited: the true half life of the metabolite shows up where? |
in the semi-log graph of the metabolite-time profile. |
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FRL: t1/2 drug ____ t1/2 metabolite |
> |
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FRL: always ____ drug in the body vs. metabolite |
more |
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FRL: the t1/2 of the metabolite appears to be the same as the drug, but is actually much ______. |
smaller; see same slope |
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ERL: t1/2 drug ____ t1/2 metabolite |
< MAY be more metabolite in the body than the drug |
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FRL: there is always ____ drug in the body vs. metabolite |
more |
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ERL: conc of metabolite at some point is ____ than the conc of parent |
bigger |
