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8 Cards in this Set

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How severe can beta-2 blockade be?
very severe. It can be severe enough to cause gangrene in patients.
List 4 mechanisms how drugs may improve angina.
1.Promotion of vasodilation of coronary arteries.
2.Reducing preload
3.reducing afterload
4.Reducing cardiac contractility and heart rate.
Nitroglycerin may reduce vascular tone through the production of nitric oxide. TRUE/FALSE
TRUE.
What is preload?
It means the tension that arises in the ventricular muscle fibers from expansion of the ventricles during diastole. Excess ventricular dilation increases preload.
How is nitroglycerin related to preload?
It improves angina partly by dilating systemic veins, so that blood pools in the veins and does not excessively fill the ventricles.
What is afterload?
It is the tension in the ventricular muscle during systolic contraction; it increases with increasing systemic arterial blood pressure, against which the ventricles must strain.
By reducing cardiac contractility and heart rate, the O2 requirement of the heart will be reduced as well. TRUE/FALSE
TRUE.
What are sympathetic blockers?
These include beta blocking drugs such as propranolol.
Calcium channel blockers(verapamil) dilate coronary arteries and limit cardiac muscle contractility through interference with the calcium influx that causes muscle contraction.