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20 Cards in this Set
- Front
- Back
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How does gastrin and CCK differ in function?
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Potency
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What syndrome occurs when non beta cell tumors of the pancreas secrete gastrin(gastrinoma)
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Zollinger- Ellison syndrome
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What are the three forms of CCK?
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CCK 39
" 33 " 8 CCK 8(octapeptide) is the most abundant and potent) |
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On which aminoacid sequence is the physiological activity located?
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On the octapeptide on the carboxy terminal.
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What are the cells that secrete CCK?
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I cells of duodenum and jejunum
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List 8 functions of CCK.
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1. Increase the gall bladder contraction
2. Lower pressure on sphincter of Oddi 3. Increase pancreatic enzyme secretion 4. Decrease gastric emptying rate 5. Increase pepsinogen secretion 6. Lower LES pressure 7. Stimulate growth of the exocrine pancreas 8. Work synergistically with secretin to increase bicarbonate secretion. |
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What are the major stimuli for CCKs secretion?
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Small peptides and L- amino acids
Fatty acids and monoglycerides |
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Why dont triglycerides stimulate the release of CCK?
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They cannot cross the intestinal membranes.
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Which systems are primarily used by CCK to exert its actions?
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Endocrine and neurocrine
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What size polypeptide is secretin?
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27 amino acids polypeptide
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Secretin was the first GI hormone to be discovered(Bayliss and Starling, 1902). TRUE/FALSE
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TRUE.
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On which aminoacid sequence is the physiological activity located?
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All 27 aa are required
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name the cells that secrete secretin.
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S cells of the duodenum
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What are the functions of secretin?
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1. Stimulates bicarbonate secretion from pancreatic and biliary duct cells.
2. Enhances activity of CCK on pancreatic secretion and gallbladder contraction 3. Lowers gastric and intestinal motility 4. Lowers HCL secretion 5. Increases pepsinogen |
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What are the major stimuli for secretins release?
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pH<4.5 in duodenum
fatty acids, amino acids and peptides in the duodenum. |
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What system is primarily used by secretin to exert its actions?
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Endocrine
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What system is primarily used by secretin to exert its actions?
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Endocrine
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What system is primarily used by secretin to exert its actions?
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Endocrine
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What other G I hormone is related to secretin?
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Glucagon(they share 14 aminoacids)
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Which hormones are part of the secretin-glucagon family?
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Secretin
Glucagon Vasoactive inhibitory peptide(VIP) GIP |
