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12 Cards in this Set

  • Front
  • Back
What is autoregulation?
Mechanism by which blood flow is altered to meet the demands of the tissue.
Which organs exhibit autoregulation?
Brain, heart and kidney
What is active hyperemia?
Blood flow to the organ is proportional to the metabolic activity of the organ.
What is reactive hyperemia?
Transient increase in blood flow to an organ after it has undergone a brief period of arterial occlusion.
What mechanisms have been proposed to explain the local control of blood flow?
Myogenic hypothesis; based on vascular smooth muscle contracting when stretched and explains autoregulation, but not active or reactive hyperemia.
metabolic hypothesis; based on tissue supply of O2 matching the tissue's demand and the production of vasodilator metabolites(CO2, H+, K+, lactate and adenosine.
What effects does Histamine and bradykinin have on vasculature?
Arteriolar dilation and venous constriction.
5-hydroxytryptomine and serotonin cause arteriolar constriction. TRUE/FALSE
Prostacyclin and E series prostaglandins(PGE1, E2) cause vasodilation. TRUE/FALSE
F series prostaglandins and thromboxane A cause vasoconstriction. TRUE/FALSE
What factors determine autoregulation in the brain?
Local metabolic factors: PCO2)
What factors determine autoregulation in the heart and kidney?
In the heart, local metabolic factors: hypoxia, adenosine and NO.
In the kidney: myogenic and tubuloglomerular feedback.
What factors determine autoregulation in skeletal muscle at rest and with exercise?
At, sympathetic innervation.
With exercise, local metabolic factors, lactate, adenosine and K+.