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5 Cards in this Set

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Tubular Actions of Angiotensin II
1.) Enhance Sodium-hydrogen exchanger in the proximal tubule and the Thick Ascending Limb --> Increased sodium reabsorption
2.) Enhanced Epithelial Sodium Channels on the collecting duct --> Increased sodium reabsorption
3.) Enhance the Tubular Glomerular Filtration
NET EFFECT: Decreased Sodium Excretion
SNS Activity
1.) Increased Renal Vascular Resistance
2.) Increased Renin Release
3.) Increased Tubular Sodium Reabsorption
NET EFFECT: Decrease Sodium Excretion
Actions of AVP (ADH)
1.) Increased water retention by adding additional AQP II channels to the apical surface of the distal nephron (Perhaps the Collecting Duct?)
2.) Increase Sodium/Potassium/Chloride cotransport in the Thick Ascending Limb
3.) Increase the epithelial sodium channel open probability in the collecting duct
OVERALL: Helps generate hypertonic medullary interstitium
NET EFFECT: Decreased Sodium Excretion
Action of ANP
1.) Renal vasodilation - increase Cortical Blood Flow and increased Glomerular Filtration Rate; Increase medullary blood flow which causes medullary washout of the interstitium
2.) Increase sodium load to Proximal Tubule and thick ascending Limb - causing increased sodium excretion
OVERALL: Decrease ANP release from atria - Decreases effective circulating Volume
NET EFFECT: Decrease sodium excretion when ANP is low!!!
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