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23 Cards in this Set
- Front
- Back
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What is clearance?
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volume of plasma cleared per unit time (Cx = Vdot * Ux / Px)
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What indicator(s) is/are used to measure GFR?
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inulin/ creatinine secretion
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What indicator is used as a measure of renal plasma flow?
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PAH
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If clearance is less than GFR, what does this tell you about reabsorption/secretion?
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there has been net reabsorption
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If GFR decreases, Pcreatinine will _____________
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increase
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Is creatinine clearance dependent or independent of urine flow?
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independent
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is BUN dependent or independent of urine flow?
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dependent
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High protein diet and enhanced tissue breakdown do what to BUN? urea production?
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increase both
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Low protein and liver disease do what to BUN? urea production?
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decrease both
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how much glucose is reabsorbed in the proximal tubule?
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almost 100%
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What is Tm?
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the plateau portion of the plasma glucose reabsorption curve
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What is threshold on the glucose secretion curve?
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the point at which glucose reabsorption no longer matches the filtered load curve. At the same point, the excretion curve reaches threshold and follows parallel to the filtered load curve.
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Is water permeability in the proximal tubule low or high?
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high
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the NKCC channels are in the ________ _________ _________ and are targets for loop __________
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thick ascending limb; diuretics
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The fluid going into the DCT is ____________
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hyposmotic
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What is the target for thiazide diuretics?
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Na+/Cl- cotransporter in the distal convoluted tubule
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ENaC is regulated by what hormone?
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aldosterone
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ENac is blocked by what?
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amiloride
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where do aquaporin channels start appearing?
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Cortical Collecting Duct
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ADH _________ water permeability
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increases
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Without ADH, urine is _________
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dilute
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Diabetes insipidous would be characterized by too little or too much ADH?
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too little
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SIADH causes what type of change in volume?
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Hypososmotic volume expansion
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