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280 Cards in this Set

  • Front
  • Back
3 types of skeletal muscle fiber
-slow-twitch oxidative

-fast-twitch oxidative glycolytic

-Fast-twitch glycolytic
skeletal muscles are named for their _____________ velocity and they way they produce ___-
contractile

ATP
Skeletal fibers are normally a mix of
3 kinds of fibers
What determines how fast or slow twitch it is?
ATPase
muscle fiber speed
-medium

-slowest

-fastest
-fast-twitch glycolytic red muscle

-slow-twitch red muscle

-fast-twitch white muscle
what is the o2 binding pigment in red blood cells
hemoglobin
Ow binding pigment in skeletal muscle
myoglobin
What has a greater affinity (attraction)

myoglobin or hemoglobin
Myoglobin
conditioning of the body to make it more fit for performing desired skills
athletic training
when gaining muscle mass, what are you doing?
Making cells bigger
increasing muscle fiber (cell) diameter due to protein synthesis-->increase # of myofibril
hypertrophy
what is the adding of cells called?
hyperplasia
Are smooth muscle contractions fast or slow
slow
What is the most common smooth muscle organization
single unit
_________________ smooth muscle is connected by __________________ and the cells contract as a _________
single unit
gap junctions
single unit
Muscle types:

Somatic nervous system


autonomic nervous system
-skeletal

-smooth
What muscle organization of smooth muscle must be stimulated independently?
multi unit smooth muscle cells
What is the protein in smooth muscles that holds bundles of actin and myosin together?
dense bodies
in_________ muscle, myosin head contract in the opposite direction
smooth
Smooth muscle use actin and myosin (much longer) but not _________ based.
sarcomere
________ muscle has Ca inside and outside
smooth
3 components of the cardiovascular system
-blood
-blood vessels
-heart
what are the functions of the cardiovascular system?
distribute oxygen and nutrients to the body's cells

remove waste

termoregulation
force-generating organ that propels blood throughout blood vessels
heart
blood circulation is one-way through _________ circuits
2
What are the 2 circuits that blood circulates through the body

-blood flow between heart and lungs

-blood flow between heart and rest of body
pulmonary

systemic
What side of the heart recieves"deoxygenated blood from the systemic circuit?

then sends it where?
right side of heart

sends to pulmonary circuit
what side of the heart recieves osygenated blood from the pulmonary circuit?

sends where?
left side of heart

systemic circuit
What keeps blood in the systemic circulation in babies?

why?
Fetal Shunts
foamen ovale (closes fossa)

lungs aren't used yet
cardiac muscle is _____________whcih means contractions are result of signals generated by the muscle itself

NOT EXTERNAL FROM THE NS
myogenic
ability to spontaneously produce action potentials in a periodic, repeatable manner
autorhythmicity
(pacemake cells)
synchronize contractile cells in cardiac muscle
autorhythmic cells (pacemakers)
Where are pacemaker cells found in the heart?
SA node

AV node
Cardiac is simular to skeletal muscle in that its functional unit of contraction is the ____
sarcomere
Contractions in the heart occur via __________________ like skeletal muscle
myosin+actin
Although cardiac and skeletal muscle are similuar, what are some major differences?
communication between cells by gap junctions

Long action potiential duration
(NO SUMMATION)
What does cardiac muscle have long action potientials?
no summation!
prevents tetanus
In _________ muscle, the muscle relaxes before another potiential can act of it
cardiac

prevents summation
action potential in the heart
1. sa node depolarizes
2.electrical activity to AV node
3.deplolarization TOP DOWN
(forces blood down)
4. blood to apex of heart
5. depolarization BOTTON UP
yeah..
what allows bottom up depolarization of the heart/
fibrous barrier
what is the primary regulator of the heartbeat?
SA node
Why is the SA node the primary regulator of the heart beat?
-generates action potentials frequently
What is the emergency backup in the heart
AV node
placement of electrodes for ECG or EKG
einthovens triangle
Why does the EKG work
-synchronized heart activity
-conductivity of body fluids
The _________ wave is a result of...
-P wave
-QRS complex
-T wave
-atrial depolarization
-ventricular depolarization and atrial repolarization
-ventricular repolarization
what are abnormal heart beats
arrhythmias
abnormally fast heart rate at resting state
tachycardia
Abnormally slow heart beat
Bradycardia
loss of synchronized heart activity
fibrilation
-SA node failure
-15% of strokes due to blood clots
A-Fib
loss of ventricle ability to pump blood
How serious?
V-fib

VERY SERIOUS
causes cardiac arrest
V-fib
sudden loss of regular heartbeat (v-fib)
loss of consciousness
Cardiac arrest
heart attack called
myocardial infarction
caused by
inadequate o2 supply to heart muscle.
-refered pain
myocardial infarction
blockage leads to
heart attack (myocardial infarction)
all events associated with the flow of blood through the heart during a single heartbeat
cardiac cycle
what is one complete cycle of atrial and ventricular contraction and relaxation
heartbeat
period of cardiac muscle contraction
systole
period of cardiac muscle relaxation
diastole
number of ventricular contractions per minute

average resting?
heart rate

70/min
amount of blood pumped per ventricular contraction

ave?
stroke volume

70 mL
How do you figure the cardiac output?
heart rate x stroke volume
___ L of blood per min per ventricle
5
the _____________ goes through the heart every _____ mins
total blood volume

1
what are some factors that affect cardiac output
change in heart rate or stroke volume
what has an impact on the heart
Nervous system

endocrine

Heart CAN work without it!
heart rate is initiated by the ___________s autorhythmic cells and Modulated by the imput from the
SA nodes
nervous and endocrine system
increases heart rate by secreting _____________
sympathetic NS
norepinephrine
decreases heart rate by secreting _______
parasympathetic NS
acetylcholine
Hormonal modulation:
_____________ secreted by adrenal medulla and _____________ heart rate.
epinephrine
increases
What is more complex?
regulation of heart rate or stroke volume
stroke volume
force with which ventricles contract
depends on end-diastolic volume
ventricular contractility
Stroke volume largely depends on
ventricular contractility
stroke volume is NOT affected by the ____________ NS
parasympathetic
What NS is the stroke volume affected by?
sympathetic NS
transcription factor protein that turns on or off genes

-found in all vertebrate hearts
Tbx5
Tbx5 studies
-genetially altered mice produced 3 chambered hearts
yep.
What are the 3 main functions of the immune system?
Self vs nonself
1.protection against disease causing (viruses,bacteria etc)
2.isolate or remove non-microbial foreign substances
3.recognize/remove abnormal cells (cancerous)
What are the 2 classes of microbes that are of primary health concern in the U.S?
viruses

bacteria
what are some non-bacterial pathogenic microbes

ex?
parasites

malaria ( bad air)
-protozoan develops in mosquito
1.transmission
2. liver
3.bloodstream
4.kill red cells
the _________________ doesn't NOT constitute a traditional "organ system"
immune system
the immune system is composed of cells found in the
-
-
-
blood
lymph system
-tissues
what type of leukocytes are in tissures and destroy non-self particles
monocytes and macrophages
another name for white blood cells
leukocytes
in the blood

most abundant wbc
injest and destroy
neutrophilis
WBCs that are part of the acquired immune system
-recognize pathogens
lymphocytes and plasma cells
WBC that release chemicals that mediate inflammation and allergic responses
basophils and mast cells
WBCs that destroy antibody coated parasites
eosinophilis
WBCs that recognize pathogens and activate other immune cells by antigen presentation in lymph nodes
dendritic cells
What in the lymphatic system in not encapsulated and has a high immune cell count
tonsils
gut associated lymph tissue
in the lymphatic system, what produce red and white blood cells?
thymus gland
bone marrow
do lymph nodes have a high or low WBC concentration
HIGH
T or F
immune cells in the lymph nodes are positioned to detect/intercept pathogens
true
What is the bodies first layer of defense that is kesigned to KEEP PATHOGENS OUT OF THE BODY
-physical
-chemical
-bahavioral
If they fail:
-Skin,nasal hairs,mucous, ciliated epithelium
-lysozyme,acidity,lactoferrin
-sneezing,coughing,washing
Immune system takes over!
present from birth
innate immunity
general defense against pathogens
innate immunity
protects against foreign substances/cells without recognizing specific identities
innate immunity
specific immunity
acquired ammunity
recognizes particular pathogen and selectively reacts to it
acquired immunity
what is the normal/ most common way to create immunity?
acquired immunity
how does active immunity work?
body is exposed to pathogen

creates antibodies
What are 2 types of immunity under acquired immunity
active

and passive
how does passive immunity work?
acquire antibodies made by another organism
in passive immunity, where could you get antibodies?
breast milk
feaces
what are 2 phagocytes
used in the immune system
macrophages
how does innate immune response work?
phagocyte ingulfs pathogen
sometime the innate immune system doesn't recognize the ___________ and the _____________- must tag it with anti body receptors
pathogen

acquired immune system
what are the 3 stages of acquired immunity?
recognition of antigen by lymphocytes

lymphocyte activation and proliferation (making of proteins)

attacks on antigen-bearing bodies
any molecule that triggers a specific immune response
antigen
these cells fight infection and are Short-lived
effector
long lived cells that produce secondary response
memory cells
memory and effector cells are part of the ___________-- immune system
acquired (active)
Is a flu shot active or passive
active
work against foreign bodies by ginding to antigens

aka
anti- body

immunoglobulin
antibodies are ____________ produced by ____________ and are either ____________or ______________--
proteins
B lymphocytes

either
inserted into cell membranes
or
released from the cell
What are the 5 classes of antibodies?
-Ig
-Ig
-Ig
-Ig
-Ig
-G
-A
-E
-M
-D
what class of antibody comprises 75% of antibodies found in blood plasma
IgG
what class of antibody involved in secondary immune response
IgG
what class of antibody is the most common
IgG
what class of antibody is found in external secretions
ex?
IgA
Saliva
tears
breast milk
what class of antibody is involved in allergic responses
IgE
what class of antibody is involved with primary immune responses and blood group antigens
IgM
what class of antibody is the most common reason for blood transplant rejection
IgM
what class of antibody is associated with IgM's but their role is unclear
IgM
Y shaped proteins
antibody
What part of an antigen determines the Ig class
Base or Fc region
an antibody is made of 2 identical ________ chains and 2 identical heavy chains linked by
light

disulfide
what is an incorrect response of the immune system?
caused by?
ex?
autoimmune disease

failure to distinguish self from non-self

type 1 diabetes
What does an overactive immune response do
allergies
out of proportion response to threat
What is it called when the immune system has no response
immunodeficiencies
if the immune has no primary immune response it is caused by:

if there is no acquired immune response it is cause by
primary- gentic defect

acquired- infection (AIDS)
women tend to "prefer" men with ____________ that are
most alike or different?
MHC genes

different!
What arteries have the most pressure
Elastic arteries
Left heart
arteries
arterioles
capilaries
venules
veins
right heart
yeah
What picks up the fluid that is lost from the capilaries?

what is this fluid called?
lympahatic system

Lymph
Once the Lymph get to the ____________ its returned back to the ___________ system
thoracic duct,
circulation
How are blood vessels classified
Direction of blood flow

size
All blood vessels possesss a ___________
which is lined by________
larger vessels are protected in _________
lumen
epithelial tissue
deeper tissue
hollow opening through which blood flows
lumen
What conduct blood away from the heart
arteries and arterioles
Arteries contain large amounts of __________&________ tissue and ________ musscle.
elastic and fibrous connective tissue
and Smooth muscle
Since __________ contain large amounts of elastic and fibrous connective tissue, they can withstand:
Arteries

Higher blood pressures
________________-
smaller than arteries
not visible by naked eye
contain little connective tissue
large amount of circular smooth muscle
Arterioles
What transport blood from arteries to capillaries
Arterioles
smallest and most numerous blood vessels

invisible to naked eye
Capillaries
Do capillaries have muscle or connective tissue?
no
consist of lumen one cell thick
capillaries
The __________s simple structure allows them to exchange materials like
____&_____ between cells and blood
capillaries

nutrients
wastes
What conduct blood to the heart
veins and venues
Veins
-__________ lumens, (_____ walls)
-can withstand _____ blood pressure
-contain one way valves
Why?
large, thin

lower

to keep blood from pooling bc of low pressure
_________
smaller than veins, not visible

some exchange
venules
transport blood from capillaries to veins
venules
What has the most smooth muscle
artery
what has the most elastic tissue
artery
has no fibrous or elastic tissue
arteriole
only has endothelium tissue
capillary
has fibrous tissue and endothelium
venule
as a little endothelium elastic , smooth and fibrous tissue
vein
what are the 2 main components of blood

what %tage of blood is plasma
plasma

cellular elements

55%
fluid that circulates in the cardiovascular system
blood
What proteins found in plasma are carriers?
blood clotting agents?
-globulins

-fibrinogen
The "cellular elements" in blood are
cells
erythrocytes
red blood cells
what are the most abundant cells in the blood (5 billion/mL)
red blood cells
why are red blood cells unique?
lack nuclei,mitochondiria,ribosomes,
what is the primary function of erythrocytes( red blood cells)

how (using what)
transport oxygen and CO2

using hemoglobin
What is a hemoblobin molecule composed of
4 protein globin chains
there are ___ hemes per molecule of hemoglobin, so each hemoglobin molecule can carry how many o2 or CO2
4
Fragments of bone marrow cells that have broken off
platelets
bone marrow cells are aka
megakaryocytes
Are megakaryocytes larger or small than erthrocytes
smalleer
T or F
Platelets are important to blood clot formation
True
Large cell with lots of DNA
megakaryocyte
what makes magakaryocytes able to get so large
mitosis 7 times withough dividing
An active _______ is spiky
platlet
another name for blood clot
thrombus
process of blood clot formation
hemostasis
what are the steps of clot formation? how?
1. vasoconstriction
2. platelet plug
2b.coagulation
3. vessel repair
1.paracrine is released by damaged tissue

2. platelets become active becuase of the paracrines and chemical changes
2b. clot forms
3. clow dissolved by plasmin
Enzyme released that converts fibrinogen to fibrin
thrombin
tissue deprived of blood by an inappropriate clot
infarct
enzyme that disolves a clot gradually
plasmin
t or f
blood clotting is simple
F

unnecessairly complex
t or f

whales lack factor XII and still clot
True
a feature that evolved under one set of conditions and becomes used for additional or different purposes
cooption
What is a clotting example of cooption?
CAMP
-evolved as intracellular messenger but is used for clotting now
substance that triggers immune response
antigen
immune response
antibodies
1.no A or B antigens.
what antibodies?
2.A antigens
what antibodies?
3.B antigens
what antibodies?
4.A and B antigens
what antibodies?
1.O
anti A and B
2. A
anti B
3. B
anti A
4. AB
no antibodies
if you have the Rh factor your have ____ blood
if you dont have the Rh factor, you have _____ blood type
positive

negative
most common blood type
O neg
universal donor
O
What is the universal acceptor blood type
AB
what are the 2 types of respiration
internal
external
cellular respiration
o2 is used in mitochondira in ATP produciton
internal respiration
exchange of O2 and CO2 between the ouside air and body tissues
external respiration
What is the main function of the respiratory system
external respiration
4 processes of external respiration
1.inspiration and expiration (between outside and lungs)
2.exchange of O2 and CO2 between ___&____
3.transportation of gas by the _______
4. exchange of O2 and CO2 between blood and cells by:
1.pulmonary ventilation
2.lungs and blood
3.blood
4.diffusion
Other functions of respiratory system besides gas exchange?
-vocalization
-pathogen defense
mucous, cilia, macrophages
-body pH
selective loss/retention of CO2
-dissipating water and heat
breathing
What allows lung movement
and
holds lungs against thoracic wall
pleural fluid
3mL
aka collapsed lung
________ can cause lung to detach from thorasic wall
Pneumothorax

to detach
Where is the main gas exchange site in the respiratory system
alveoli
in airways in the respiratory system, division__________- and diameter__________-
increase

decrease
what has the total SA of a racket ball court
Lung
The _____________-- contains 10% of total blood volume
pulmonary circuit
each __________ has extensive capilary beds
alveolar sac
In an alveolar structure, what is the ______ cell for?
type1-
type 2-
most common cell gas exchange

synthesizes surfactants
secrete sirfactin that keeps cells lubricated for expansion
At rest, the intra-alveolar pressure is
equal to atmospheric pressure
air flow into and out of lungs is driven by:
-lungs expand= pressure down
-lungs shrink= pressure up to push out air
pressure gradients
What are somePhysical factors affecting ventilation
-air pressure gradient
-airway resistance
^ gradient= ^ ventiliation

down resistance= ^ventilation
respiratory neurons in the _______- control inspiration and expiration
medulla oblongata
respiratory neurons in the _______ modulate ventilation
pons
rhythmic breathing pattern due to spontaneously dischanging neurons
respiratory pacemakers?
ventilation can be modulated by
higher brain centers

emotion,sickness chemicals etc
What 3 things are used for inspiration
scalene and sternocleidomastoid muscles

external intercoastals

diaphragm
what 2 things are used for expiration
internal intercostals

abdominal muscles
in ventilation, the ____&____ get feedback from different places
pons and medulla oblongata
Your inner fish:
why do we get hiccups
pathway that fish use to breathe
what causes hiccups
diaphragm spasm
brief paralysis of diaphragm
getting wind knowcked out of you
what do condon think stimulates the mother to give birth?
surfactant protein A levels get higher
What is a function of the kidneys?

most important?
waste removal

Water and Ion homeostasis
the kidneys play a role in the hormones ___ which do?
-erythropoletin (EPO)
-calcitriol (v D3)
-renin (enzyme)
-increases red blood cell production

-Ca balance and metabolism

-aldosterone regulation (Na balance
T of F
kidneys have a tremendous reserve capacity
true
most of the ______ isn't used
kidneys
t or f
1 in 1000 people live just fine with 1 kidney
t
____ to _____ percent of cardiac output is going to the kidneys
20-25 %
In the kidneys,what is left in the _________ goes to the bladder
nephrons
2 capillary networks directly connected by blood vessels
portal system
Filtration is ________- and __________
passsive and nonselective
movement of fluid, solutes from blood (arterioles) to lumen of nephron (bowmans capsule)
filtration
functional unit of kidney
nephron
what does filtration
bowman's capsule
where reabsorption occurs
proximal tubule
Reabsorption can be
passive or active
and selective about what is taken back to the body
What is the fundamental principle concerning the kidneys
Filter EVERYTHING
reabsorb SELECTIVELY
secretion is ________ and______
active and selective
movement of fluid, solutes from the blood bakc to lumen of nephron
secretion
end-product of A-C = urine

leaves nephron (collecting duct) through ureter to bladder
excretion
the excretion process is :
passive
What is in the ________- duct is unrecoverable
collecting
where is the bulk of the filtration and secretion done
peritubular capillaries
20% is filtered and is realitively constant in the nephron, but 19% is reabsorbed back (of the 19%0
filtration fraction
100% plasma enters arteriole,
80% plasma entering kidney returns to circulation

20% filtered
of the 20%, 19 is reabsorbed
yeahhhh
urination
micturition
the bladder is made of ____ muscle
smooth
the bladder is in continuous contact with ___________ neurons
why?
motor neurons

keeps bladder contracted
nocturnal enuresis
bedwetting
if its not psychological, bedwetting can be caused by the loss or delayed development of circadian rhythum of______
vasopressin (ADH)
number of particles (free ions and molecules) per liter of water
osmolarity
^ number of particles=
^ osmolarity
T or F
Water can be make by metabolism
true
Where can we conserve water>?
urine
Water gain and loss are
equal
The ___________- can only ________ fluid. they cannot restore ___________ volume
kidneys conserve

lost
________ stops if water level is too low
filtration
Quick redistribution

slow redistribution
cardiovascular system
respiratory system

kidneys
behavior (from hypothalamus)
Osmolarity drops from ______- to ____ when you get to the _________
300 to 100

loop of Henle
what has a very large range of osmolarity
urine
what controls the distal nephrons permeability to water and solutes
hormones
fluid movement in close proximity but in opposite directions
what capillary does it use
countercurrent exchange

vasa recta
How do concentration gradients in the Kidneys stay constant?
countercurrent exchange
ions and water that are being reabsorbed are picked up by blood vessels
What hormones help the body decide what to reabsorb?
Vasopressin
More ___________ = more water reabsorption

released from ?
made by?
Vasopressin

posterior pituitary
hypothalamus
Vasopressin action
1. binds to ___________ receptor
2. Activates_________ system
3.inserts ____ into membrane
4. creates gates for H2O to go to blook vessels
1.membrane
2.second messenger
3.aqua porins
What are the 3 inputs that can trigger Vasopressin release?
-__________ greater than ___
-________ _______ stretch bc of low blood volume
-__________ blood pressure
-osmolarity;280
-decreased atrial
-decreased
What steroid controls sodium potassium ballance?
where is it from?
Aldosterone

adrenal cortex
Aldosterone Action
1. binds with_____ in cell
2.initiates ____ in nucleus
-makes new:
3.Proteins made in nucleus modify existing ________
4.Result=
1.cytoplasmic receptor
2. transcription
new pumps and channels
3. proteins
4. increased na apsorbtion and K secretion
What animal can produce urine more consentrated than sea water

why
kangaroo rat and Camel

Long loops of Henle
what controls the distal nephrons permeability to water and solutes
hormones
fluid movement in close proximity but in opposite directions
what capillary does it use
countercurrent exchange

vasa recta
How do concentration gradients in the Kidneys stay constant?
countercurrent exchange
ions and water that are being reabsorbed are picked up by blood vessels
What hormones help the body decide what to reabsorb?
Vasopressin
More ___________ = more water reabsorption

released from ?
made by?
Vasopressin

posterior pituitary
hypothalamus
Vasopressin action
1. binds to ___________ receptor
2. Activates_________ system
3.inserts ____ into membrane
4. creates gates for H2O to go to blook vessels
1.membrane
2.second messenger
3.aqua porins
What are the 3 inputs that can trigger Vasopressin release?
-__________ greater than ___
-________ _______ stretch bc of low blood volume
-__________ blood pressure
-osmolarity;280
-decreased atrial
-decreased
What steroid controls sodium potassium ballance?
where is it from?
Aldosterone

adrenal cortex
Aldosterone Action
1. binds with_____ in cell
2.initiates ____ in nucleus
-makes new:
3.Proteins made in nucleus modify existing ________
4.Result=
1.cytoplasmic receptor
2. transcription
new pumps and channels
3. proteins
4. increased na apsorbtion and K secretion
What animal can produce urine more consentrated than sea water

why
kangaroo rat and Camel

Long loops of Henle