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20 Cards in this Set
- Front
- Back
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what is the term for "stop bleeding"
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hemostasis
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what are the 3 hemostatic mechanisms
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1. formation of a platelet plug (thrombus)
2. production of web of fibrin proteins that penetrates and surround the platelet plug 3. vasoconstriction |
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what is another name for platelets
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thrombocytes
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do platelets have a nucleus?
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no
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platelets are made by pinching off pieces of specialized bone marrow cells called....
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megakaryocytes
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what is the average life span of a platelet?
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5- 9 days
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what is normal platelet count per cubic millimeter
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130,000- 400,000 platelets
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what are the 2 inhibitors that the endothelium releases that inhibit platelet aggregation
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nitric oxide (NO) and prostacyclin (PGI2)
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what is the enzyme expressed on endothelial cells that breaks ATP down to AMP
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CD39
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when platelets stick to collagen and vWF, change shape and release ADP, serotonin, and thromboxane A2. This is called....
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platelet release reaction
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this irreversibly inhibits the enxyme that synthesized thromboxane A2 in the platelets reducing the stimulus for platelet activation and the likelyhood of a MI
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daily low dose aspirin
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this blocks the platelet ADP receptor- inhibiting platelet activation
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clopidogrel (Plavix)
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what are the activators in the extrinsic pathway
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tissue factor (thromboplastin)
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what are the activators in the intrinsic pathway
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collagen and negatively charged surface
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which pathway is fast or slow?
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extrinsic
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an X-linked recessive trait prevalent in the Royal families of europe.
- due to defect in a subunit of factor VIII - results in reduced clotting- increased bleeding |
hemophilia A
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a defective vWF results in poorer binding of platelets to the subendothelium and vWf also preotects clotting factor VIII
- results in reduced clotting- icreased bleeding |
Von Willebrand's disease
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a type of anticoagulant that prevents clotting by activating a natural anticoagulant in the blood called antithrombin
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heparin
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type of anticoagulant that prevents clotting by inhibiting the synthesis of vitamin K dependent clotting factors
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warfarin
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after a clot forms, this circulating substance coats the fibrin meshwork
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plasminogen
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