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12 Cards in this Set
- Front
- Back
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___________ are permeable to ions and conduct electrotonic current between cells
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connexons
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What is the sequence of activation at a chemical synapse?
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Depolarizing signal travels down the pre-synpatic axon to reach the terminal bouton -> Ca++ channels in the terminal bouton open and let in Ca++ which allows synpatic vesicles to bind to the membrane and release neurotransmitters into the synpatic cleft -> NTs bind to post-synaptic receptors
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NTs are removed from the synaptic cleft by what two mechanisms?
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degradation and reuptake
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What are the two types of Ach receptors?
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Muscarinic (metabotropic) and Nicotinic (ionotropic)
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Neuromuscular transmission occurs at the _____ ______ ______
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motor end plate
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The neurotransmitter at the neuromuscular junction is _______
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ACh
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____________ is used to degrade ACh at the motor end plate
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Acetylcholinesterase
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The amount of ACh released at the motor end plate determines the magnitude of the ____ _____ ______
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end plate potential
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ACh is broken down into ______ and ________ in the __________ and repackaged to ACh in the ____________
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Acetyl CoA, Choline, Synaptic cleft, nerve terminal
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By what mechanism does botulism toxin reduce vesicle release
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It binds to SNARE proteins
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_________ and __________ sum together to determine a synaptic potential
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Excitatory Post Synaptic Potentials, Inhibitory Post Synaptic Potentials
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Tetanus toxin prevents NT release by what mechanism and causes what effects?
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Binds to synaptobrevin, preventing the vesicles from docking on the t-SNARES on inhibitory interneurons causing "lock jaw"
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