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9 Cards in this Set

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  • Back
What is peptide YY?
It is involved in food inhibiting activity. It also inhibits gastric acid secretion and motility and is a good candidate to be the gastric inhibitory peptide.
What is Neurotensin?
It is a 13 amino acid polypeptide, and produced by neurons and cells that are abundant in the mucosa of the ileum.
Its release is stimulated by fatty acids and it inhibits GI motility and increases ileal blood flow.
What is substance P?
It is found in endocrine and nerve cells in the GI tract and may enter the circulation. It increases motility of the small intestine.
What is GRP?
It contains 27 amino acid residues and the 10 amino acid residues at its carboxyl terminal are almost identical to those of amphibian bombesin.
It is present in vagal nerve endings that terminate on G cells and is the neurotransmitter producing vagally mediated increases in gastrin sectretion.
Glucagon from the GI tract may be responsible(at least in part for the hyperglycemia after pancreatectomy. TRUE/FALSE
What is Guanylin?
Is a polypeptide of the GI tract that binds to guanylyl cyclase. It consists of 15 amino acid residues and secreted by cells of the intestinal mucosa.
Stimulation of guanylyl cyclase increases what?
It increases the concentration of intracellular cGMP, and this causes increased activity of the cystic fibrosis regulated Cl- channel and increased secretion of Cl- into the intestinal lumen.
Is there any similarity between Guanylin and certain strains of E. coli?
The heat stable enterotoxin of certain starins of E. coli has a structure very similar to guanylin and activates guanylin receptors in the intestine.
Are guanylin receptors found elsewhere?
They are also found in the kidneys, the liver and the female reproductive tract, and it may act in an endocrine fashion to regulate fluid movement in these tissues as well.