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6 Cards in this Set
- Front
- Back
How much water is reabsorbed in the body per day?
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9L
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How much water is reabsorbed in the small intestine per day? Max?
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7L/day
2x max |
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How much water is reabsorbed in the large intestine per day? Max?
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2L/day
2x max |
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What are the two types of cell connections in the cells of the small intestine and large intestine?
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Small intestine & proximal renal tubule:
LEAKY, isotonic absorbate Colon & distal renal tubule: TIGHT, hypertonic absorbate |
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What are two causes of water secretion into the crypt space?
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VIP --> ^cAMP --> ^[Ca] in --> activation of Cl- channel on the apical membrane --> lumen becomes negative --> diarrhea
Cholera toxin --> bind to basolateral receptor --> ^adenylyl cyclate --> ^cAMP --> diarrhea |
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What are 3 types of diarrhea?
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1. Increased osmotic load - increased water retention in the lumen. ie lactose intolerance, Mg containing antacids, inflammatory bowel disease
2. Excessive secretion of electrolytes "secretory diarrhea". ie cholera toxin, VIPoma, bile salt malabsorption. 3. Altered intestinal motility - rapid transit of the colon. ie IBS, diabetic neuropathy |