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47 Cards in this Set
- Front
- Back
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Saturated Vapor Pressure
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At equilibrium the partial pressure exerted by the vapor
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Gas in Solution
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-At equilibrium the liquid is saturated with gas.
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Henry's Law
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Double Pressue
Double Solubility Temp = Constant |
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Henry's Law
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amount of gas abs. by a liquid is directly proptional to part press of gas in eqilibrium with the liquid
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Henry's Law
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Amount of anesthetic vapor absorbed into the blood is directly proptional to part press of the anesthetic in the alveoli
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If temperature is not held constant and a gas is heated
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Gas comes out of solution
(pop can in the sun) |
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Bunsen Solubility Coefficient
Nitrogen at const temp @ 760 = ___ml N2/1L H20 |
14 ml
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Bunsen Solubility Coefficient
Nitrous Oxide at const temp @ 760 = ___ml N2/1L H20 |
39 ml (Nitrous is more soluble than Nitrogen)
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pertains to the solubility of gas in liqid using STP
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Bunsen Solubility Coefficient
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Oswald Solubility Coefficient
Nitrous Oxide at37 temp @ ambient pressue = ___ml N2/1L H20 |
39 ml N20/1000ml in Blood
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Oswald Solubility Coefficient
Nitrous Oxide at 37 temp @ ambient press = ___ml N2/1L Blood |
470 ml in Blood (Nitrous more soluble in the blood than H20)
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The solubility of a Gas
Depends upon |
-Partial Pressue
- Temperature - Gas & Liquid Concerned |
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Ostwald Solubility Coefficient (used in ans)
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volume of gas which dissolves in one unit volume of liquid at the temperature concerned
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Ostwald Solubility Coefficient (used in ans)
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volume of gas is not corrected to STP, measured at ambient temp/pressure
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Double pressure @ constant temp and volume reamins the same.
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Boyles Law
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Partition Coefficient
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ratio of a subst in one phase compared to another
- two phases being = vol. and in equilibrium |
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Partition Coefficient
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Specify the phases of concern in correct order
- temp should be specified |
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Blood Gas Partition Coeffcient
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at equilibrium concentration in blood = 47ml, the ratio of that to the unit volume
47/100 = .47 |
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Blood Gas Partition Coeffcient
N2O in Blood = total of 1L, 37 C, 470ml N20/1L = |
47 per 100ml = .47
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Blood/Oil Partition Coefficient
Oil + Bld = 1L 1.4 L N20 in Oil 470ml N20 in Bld |
= .47/1.4 = 0.33
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At equal pressure & 37C what is the Solubility Coefficient of N20
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= .47L
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At equal pressure & 37C what is the Solubility Coefficient of Halothane
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= 2.3 L
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At equal pressure & 37C what is the Solubility Coefficient of Ether
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= 12 L
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The _____ soluble the longer it will take to build tension in the alveoli
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more
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With gas the blood must be saturated prior to building ______in the alveoli
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tension
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With gas the blood must be saturated prior to building tension in the alveoli prior to building tension in the ___
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brain
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Where do we want to keep anesthetic gas
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Alveoli
Keeping the Alveoli tension high. |
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FA =
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Fraction Alveolar
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Fi =
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Fraction inspired
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Solubility in blood:
Des |
.42
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Solubility in blood:
Sevo |
.68
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Solubility in blood:
Halothane |
2.4
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Solubility in blood:
Forane |
1.4
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What is considered low solubility
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< 1
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What is considered high solubility
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4-5
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Low blood solubility example
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N20
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Medium blood solubility example
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Halothane
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High blood solubility example
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Ether
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The wake up curve for low solubility =
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low solubility = short wake up time
(fast to sleep, fast to wake up) |
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The wake up curve for high solubility =
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Long time to go to sleep, long time to wake up.
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Higher solubility takes away from alveolar tension and takes _____ to take effect
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longer, absorb in blood readily. (low solubility works faster)
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Oil gas partition(37C)
N20 |
=1.4 (more soluble in oil than bld)
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Oil gas partition(37C)
Ether |
= 65 less soluble than halothane (opposite in blood)
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Oil gas partition(37C)
Halothane |
= 224
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Minimum Alveolar Conc (MAC)
%vol at 1 ATM |
= a dose, indicates potentcy
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Solubility coefficient in oil is an indication of
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the potentcy
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Increased oil solubility =
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increased potentcy
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