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### 47 Cards in this Set

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 Saturated Vapor Pressure At equilibrium the partial pressure exerted by the vapor Gas in Solution -At equilibrium the liquid is saturated with gas. Henry's Law Double Pressue Double Solubility Temp = Constant Henry's Law amount of gas abs. by a liquid is directly proptional to part press of gas in eqilibrium with the liquid Henry's Law Amount of anesthetic vapor absorbed into the blood is directly proptional to part press of the anesthetic in the alveoli If temperature is not held constant and a gas is heated Gas comes out of solution (pop can in the sun) Bunsen Solubility Coefficient Nitrogen at const temp @ 760 = ___ml N2/1L H20 14 ml Bunsen Solubility Coefficient Nitrous Oxide at const temp @ 760 = ___ml N2/1L H20 39 ml (Nitrous is more soluble than Nitrogen) pertains to the solubility of gas in liqid using STP Bunsen Solubility Coefficient Oswald Solubility Coefficient Nitrous Oxide at37 temp @ ambient pressue = ___ml N2/1L H20 39 ml N20/1000ml in Blood Oswald Solubility Coefficient Nitrous Oxide at 37 temp @ ambient press = ___ml N2/1L Blood 470 ml in Blood (Nitrous more soluble in the blood than H20) The solubility of a Gas Depends upon -Partial Pressue - Temperature - Gas & Liquid Concerned Ostwald Solubility Coefficient (used in ans) volume of gas which dissolves in one unit volume of liquid at the temperature concerned Ostwald Solubility Coefficient (used in ans) volume of gas is not corrected to STP, measured at ambient temp/pressure Double pressure @ constant temp and volume reamins the same. Boyles Law Partition Coefficient ratio of a subst in one phase compared to another - two phases being = vol. and in equilibrium Partition Coefficient Specify the phases of concern in correct order - temp should be specified Blood Gas Partition Coeffcient at equilibrium concentration in blood = 47ml, the ratio of that to the unit volume 47/100 = .47 Blood Gas Partition Coeffcient N2O in Blood = total of 1L, 37 C, 470ml N20/1L = 47 per 100ml = .47 Blood/Oil Partition Coefficient Oil + Bld = 1L 1.4 L N20 in Oil 470ml N20 in Bld = .47/1.4 = 0.33 At equal pressure & 37C what is the Solubility Coefficient of N20 = .47L At equal pressure & 37C what is the Solubility Coefficient of Halothane = 2.3 L At equal pressure & 37C what is the Solubility Coefficient of Ether = 12 L The _____ soluble the longer it will take to build tension in the alveoli more With gas the blood must be saturated prior to building ______in the alveoli tension With gas the blood must be saturated prior to building tension in the alveoli prior to building tension in the ___ brain Where do we want to keep anesthetic gas Alveoli Keeping the Alveoli tension high. FA = Fraction Alveolar Fi = Fraction inspired Solubility in blood: Des .42 Solubility in blood: Sevo .68 Solubility in blood: Halothane 2.4 Solubility in blood: Forane 1.4 What is considered low solubility < 1 What is considered high solubility 4-5 Low blood solubility example N20 Medium blood solubility example Halothane High blood solubility example Ether The wake up curve for low solubility = low solubility = short wake up time (fast to sleep, fast to wake up) The wake up curve for high solubility = Long time to go to sleep, long time to wake up. Higher solubility takes away from alveolar tension and takes _____ to take effect longer, absorb in blood readily. (low solubility works faster) Oil gas partition(37C) N20 =1.4 (more soluble in oil than bld) Oil gas partition(37C) Ether = 65 less soluble than halothane (opposite in blood) Oil gas partition(37C) Halothane = 224 Minimum Alveolar Conc (MAC) %vol at 1 ATM = a dose, indicates potentcy Solubility coefficient in oil is an indication of the potentcy Increased oil solubility = increased potentcy