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13 Cards in this Set

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  • Back
Stimuli (3) that cause endothelial cells to produce endothelial derive relaxing factor aka
1. Bradykinin, stretch, acetylcholine
2. NO
NO causes and is derived from
vasodilation
endothelial cells
Prostacyclin is produced and causes
endothelial cells
(inhibits platelet aggregation) and promotes vasodilation
Endothelin1 cayses and is produced
most potent vasoconstrictor agent known
produced and secreted by endothelium
constricts vascular smooth muscle (intense vasoconstriction of coronary arteries)
Thromboxane causes and is produced
platelet aggregation and vasoconstriction
produced in platelets
Histamine causes and is produced
Ateriolar dilation, increased capillary permeability, tissue edema (decrease venous return), contraction of visceral smooth muscle
Stored in granules
NE is produced and causes
stored in granules in presynaptic terminals of chromaffin cells in the adrenal medulla
causes stimulation of alpha 1 receptors in arterioles (vasoconstriction)
EPI is produced and causes
Is produced and stored in chromaffin cells in the adrenal medulla
it causes stimulation of alpha1 receptors to cause vasoconstriction
Angiotensis II is produced and causes
produced by activation of RRAS
it is an extremely potent vasconstricting agent of arterioles & acts on them to increase TPR
Vasopressin is produced and casuses
stored in vesicles at nerve endings
Extremely (2nd most) potent endogneous vasoconstrictor
-during hemmorhage it restores Pa to normal
Bradykinin is formed and causes
formed in circulation
-causes arteriolar dilation, increased capillary permeability, contraction of visceral smooth muscle.
Stimulators of endothelin1 secretion
Angiotensin II
Catecholamines
Hypoxia
Shear Stress
Inhibitors of endothelin1 secretion
NO
Prostacyclin