Phys - Exam 3 - Gi

Front 1

Ach - site of production

Back 1

- parasympathetic nerves
- enteric nerves

Front 2

Ach - stimulus for production

Back 2

Neural reflexes

Front 3

Ach - effect on motility

Back 3

STIMULATES motility in esophagus, stomach, small intestine

Front 4

Ach - effect on secretion

Back 4

STIMULATES secretion in the salivary glands, stomach (secretion of acid, pepsinogen), pancreas (stimulates enzyme secretion)

Front 5

Ach - effect on gallbladder

Back 5

STIMULATES contraction

Front 6

Cholecystokinin (CCK) - site of production

Back 6

I cells in dudodenal, jejunal mucosa

Front 7

CCK - stimulus for production

Back 7

FATTY CHYME
- partially digested proteins, a.a.
- neural stimulation

Front 8

CCK - effect on stomach

Back 8

DECREASES motility and delays emptying; inhibits acid secretion
- REDUCES hunger

Front 9

CCK - effect on small intestine

Back 9

stimulates motility

Front 10

CCK - effect on GB and pancreas

Back 10

GB - stimulates contraction to expel bile; relaxes spincter of Oddi
Pancreas - stimulates enzyme secretion; potentiate action of secretin

Front 11

Gastric Inhibitory Polypeptide (GIP) - site of production
AKA - glucose-dependent insulinotropic peptide

Back 11

K cells in duodenal, jejunal mucosa

Front 12

GIP - stimulus for production

Back 12

- Fatty chyme
- glucose containing chyme

Front 13

GIP - inhibits?

Back 13

-Stomach: inhibits acid secretion
- SI: inhibit motility; stimulates secretion in the duoden.

Front 14

GIP - effect on pancreas?

Back 14

Stimulates insulin release

Front 15

GIP - effect on adipose tissue and skeletal muscle

Back 15

- Stimulates lipid synthesis in adipose tissue
- Increases glucose use by skeltal muscle

Front 16

Gastrin - site of production

Back 16

G-cells in gastric antrum and duodenum

Front 17

Gastrin - stimulus for production

Back 17

- Protein, aa, Ca, alcohol
- elevated gastric pH
- Gastric distension
- Neural reflexes, Ach (gastrin release inhibited by pH<2-3 in gastrin lumen)

Front 18

Gastrin - effect on stomach and small intestine and large intestine

Back 18

- stomach: stimulates motility (to enhance gastric empything) and secretion of acid, pepsinogen
- SI: stimulate motility
- LI: stimulate mass mvmt

Front 19

Gastrin - effect on ileocecal valve?

Back 19

RELAXATION

Front 20

Gastrin - effect on LES?

Back 20

contraction

Front 21

Gastrin - effect on GB and pancreas

Back 21

GB - mild contraction

Pancreas - mild stimulation of enzyme, HCO2, secretion

Front 22

Histamine - site of production

Back 22

- Stomach mucosa (entero-chromaffin cells)

- Mast cells

Front 23

Histamine - stimulus for production

Back 23

- Gastrin
- Food in stomach
- Ach
- Irritation

Front 24

Histamine - effect on stomach

Back 24

- stomach: stimulate acid secretion

- SI: stimulate secretions, esp Cl

Front 25

Motilin - site of production

Back 25

Endocrine cells in dudenal, jejunal mucosa

Front 26

Motilin - effects

Back 26

- Regulate interdigestive migrate myoelectric complex

- LES< gastric, SI contraction

Front 27

Nore, epi - site of production

Back 27

Sympatheric nerves

- adrenal medulla

Front 28

Norepi and epi - stimulus

Back 28

Neural reflexes

Front 29

Norepi and epi - targets?

Back 29

- Relaxes GI smooth muscle, except constricts sphincters
- Inhibits secretion
- Decreases blood flow

Front 30

Secretin - site of production

Back 30

S cells in duodenal, jejunal mucosa

Front 31

Secretin - stimulus for production

Back 31

ACIDIC CHYME

- partially digested protein, fats, hyper and hypo
- irritants in chyme (bile salts)

Front 32

Secretin - effect on stomach and SI

Back 32

- stomach: decreases motility (delay emptying) and secretions

- SI: inhibit motility

Front 33

Secretin - effect on LIVER

Back 33

Increase bile output, especially ductal secretion of HCO3

Front 34

Secretin - effect on GB and pancreas

Back 34

GB - potentiate CCK's action to contract

Pancreas - stimulate secretion of HCO2; potentiate CCK's action on enzyme secretion

Front 35

Somatostatin - site of production

Back 35

Enterochromaf-fin D cells in gastric and duodenal mucosa

Front 36

Somatostatin - stimulus for production

Back 36

- Food in the stomach
- Acidic pH in stomach
- neural reflexs

Front 37

Somatostatin - INHIBITS?

Back 37

- Inhibits release of neuroendocrine factors
- Stomach: INHIBITS secretion
SI:increase fluid absoption; INHIBITS secretion
- Pancreas: inhibits secretion

Front 38

Somatostatin - effects on the liver

Back 38

DECREASE bile flow

Front 39

Vasoactive Intestinal Peptide (VIP) - site of production

Back 39

- Duodenal mucosa
- Eneteric neurons
- CNS and PNS

Front 40

VIP - stimulus for production

Back 40

CHYME containing partially digested food

Front 41

VIP - what does it do to GI smooth muscle?

Back 41

RELAXES SM, including sphincters

Front 42

VIP - effect on stomach?

Back 42

DECREASES acid secretion

Front 43

VIP - effect on intestine and pancreas

Back 43

I: stimulates secretion, SM relaxationi

P: INCREASE secretion; ? regulate release of insulin glucagon

Front 44

VIP - effects on cardiovascular system

Back 44

DILATES CAPILLARIES

Front 45

INCREASES GASTRIC MOTILITY

Back 45

- Ach
- Gastrin
- Histamine

Front 46

DECREASES gastric motility

Back 46

- VIP
- GIP
- Secretin
- CCK

Front 47

INCREASES motility in the Small Intestine

Back 47

- CCK
- Gastrin
- Ach

Front 48

DECREASES motility in the SI

Back 48

- Secretin
- GIP

Front 49

Increase Gastric Motility

Back 49

ACh
Gastrin

Front 50

Decrease Gastric Motility

Back 50

Secretin

Front 51

Increase Gastric Secretion

Back 51

ACh
Gastrin
Histamine

Front 52

Decrease Gastric Secretion

Back 52

Secretin

Front 53

Increase SI Motility

Back 53

ACh
CCk
Gastrin

Front 54

Decrease SI Motility

Back 54

GIP
Secretin

Front 55

Increase SI Secretion

Back 55

ACh
VIP
Histamine
GIP

Front 56

Decrease SI Secretion

Back 56

Somatostatin