Phys 501 - Exam 4 - Fall 2013

Front 1

At a constant temp, the amt of a given gas dissolved in a given type and volume of liquid is directly proportional to the partial pressure of that gas in equilibrium with that liquid.

Back 1

P = kc - Henry's law

Front 2

What is the main method of oxygen transport?

Back 2

Hemoglobin-bound oxygen

Front 3

Is oxygen very soluble in plasma?

Back 3

No

Front 4

100 ml of plasma will dissolbe _______ ml of O2 per mmHg PO2.

Back 4

0.0032

Front 5

Only _______ O2 is directly available to the tissues.

Back 5

Dissolved

Front 6

Hemoglobin has __ heme groups.

Back 6

4

Front 7

Hemoglobin has 4 globins: ___ alpha and ___ beta.

Back 7

2; 2

Front 8

Oxygen binds to the ____ ____.

Back 8

Heme group

Front 9

There is a large ___ between the venous return and the alveoli.

Back 9

Gradient

Front 10

Diffusion of O2 stops when capillary and alveolar partial pressure of O2 is _____.

Back 10

Equal (no more gradient)

Front 11

Binding of oxygen to hgb follows the ____ ___ ____ ____.

Back 11

Law of mass action

Front 12

Saturation of hgb is a measure of mow much _____ is bound to _____.

Back 12

Oxygen; hgb

Front 13

The more O2 that binds to hgb, the more _____ the affinity for O2 that the hgb has.

Back 13

Increased

Front 14

Saturation of hemoglobin follows a _______ curve.

Back 14

Sigmoidal

Front 15

The second, third, and fourth oxygens bind to hgb via ____ ______.

Back 15

Positive cooperativity

Front 16

On the oxy-hemoglobin dissociation curve, what does the y-axis represent?

Back 16

O2 bound to Hgb

Front 17

On the oxy-hemoglobin dissociation curve, what does the x-axis represent?

Back 17

O2 dissolved in blood

Front 18

Hemoglobin is willing to dissociate from oxygen at lower _____ ________.

Back 18

Partial pressures

Front 19

When venous return blood is at PaO2 of 40, O2 bound to Hgb is still at _____.

Back 19

75%

Front 20

Only ____ of oxygen is unloaded from Hgb at the systemic tissues.

Back 20

25%

Front 21

The oxygen-carrying capacity of the blood takes into consideration the dissolved oxygen and the _____ ___.

Back 21

Bound O2

Front 22

When saturated, 1 gram of Hgb carries _____ of oxygen.

Back 22

1.39 ml

Front 23

Dissolved O2 + bound O2 =

Back 23

Blood oxygen content

Front 24

To find the dissolved O2 content you multiply the _____ by the _____.

Back 24

0.0032; PO2

Front 25

To find the bound O2 content you multiply the _____ by the ____ by the ______.

Back 25

1.39; Hgb; SO2

Front 26

A _______ shift is good for us because it ______ unloading of the O2.

Back 26

Rightward; favors

Front 27

A ______ shift is bad for us because it ________ _________ unloading of the O2.

Back 27

Leftward; doesn't favor

Front 28

At any rightward shift you have ____ O2 saturated Hgb.

Back 28

Less

Front 29

At any leftward shift you have _____ O2 bound to Hgb.

Back 29

More

Front 30

When a person is more metabolically active, they need _____ O2 for cellular respiration.

Back 30

More

Front 31

An increase in temp _____ Hgb affinity for O2, which is a _______ shift.

Back 31

Decreases; rightward

Front 32

When oxygen binds to Hgb, ______ are released.

Back 32

H+

Front 33

In the presence of more H+, oxygen is ______.

Back 33

Released

Front 34

Active tissues produce H+ which _____ oxygen unloading.

Back 34

Increases

Front 35

When the pH is lower, the curve shifts to the ______, and O2 is _____..

Back 35

Right; released

Front 36

Most of the effect of CO2 is a result of the effect of CO2 on H+ concentration, and thus pH.

Back 36

Bohr effect

Front 37

The end-product of red cell metabolism is ______.

Back 37

2,3-DPG

Front 38

2,3-DPG production is ________ in RBCs under conditions of low O2 such as anemia and high altitude.

Back 38

Heightened

Front 39

2,3-DPG _____ affinity of Hgb for oxygen, this is a _______ shift.

Back 39

Diminishes; right