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30 Cards in this Set
- Front
- Back
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How are Tetracyclines administered?
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Orally; may be cheleated by calcium-containing products
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How are Tetracyclines distributed?
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wide distribution including saliva, breast milk, and transplacental distribution
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What's the half-life for Tetracyline?
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2 hours
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How is Tetracycline concentrated (metabolized)?
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Concentrated by the liver, excreted into the intestines via bile leading to enterohepatic circulation which prolongs activity
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What are the forms of Tetracyclines?
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doxycline and minocycline (later two excreted in urine)
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What are the adverse reactions to Tetracyclines?
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Primarily gastrointestinal
(anorexia, nausea, vomiting, diarrhea, stomatitis, xerostomia) |
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What are the superinfections for Tetracyclines?
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Moniliasis and Psuedomembranous colitis
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Where is another place Tetracyclines are concentrated?
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In developing teeth and bones resulting in intrinsic staining (contraindicated in second half of pregnancy through age 8)
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What are some damages that might occur with Tetracycline use?
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Liver damage may result from IV use, kidney damage from outdated drugs, anemia, photosensivity, and vertigo
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True or False.
Hypersensitivity to tetracyclines is unusual? |
True
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What are Tetracyclines antagonistic to?
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other bacterial antiinfectives
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What is the use for Tetracyclines dentally?
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for periodontal infective agents
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Tetracyclines are not indicated for?
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Prophylactic use against B-E unless infective agent Aa
* We don't prescribe for patients with heart murmurs |
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What's a type of Clindamycin?
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Cleosin
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Tetracyclines are a bacteriostatic antibiotic against what?
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gram+, some gram- and anaerobic Bateroides
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Clindamycin interferes with?
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Protein synthesis
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How is Clindamycin administered?
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Orally, topical, IM,IV
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What's the half-life for clindamycin?
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2.5 hours
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Where is clindamycin metabolized?
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In the liver, excreted in feces (bile) and urine
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Clindamycin is anatagonistic to?
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erythromycin by competing for same binding sites?
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What are the adverse reactions to clindamycin?
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GI (nausea, diarrhea, vomiting and pseudomembranous colitis)
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What is are the superinfections for Clindamycin?
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Monilia, allergy, low blood counts, some liver and kidney dysfunction
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What is Clindamycin useful for?
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Premed (pen allergy),and oral anaeorbic infections esp. perio
*treatment for periodontal disease |
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synthetic antiinfective, active against Trichomonas, amebicidal and bactericidal against obligate anaerobes
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Metronidazole (Flagyl)
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What does Metronidazole (Flagyl) destroy?
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It destroys ring structure of DNA
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What type of effect does Metronidazole (Flagyl) have?
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Anti-inflammatory effect
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What's the half-life for Metronidazole (Flagyl)?
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8 hours
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Where is Metronidazole (Flagyl) concentrated?
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In crevicular fluid, less in the CSF, saliva and breast milk
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What are some adverse effects for Metronidazole (Flagyl)?
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GI, xerostomia, metallic taste, CNS, renal toxicity
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What does Metronidazole (Flagyl) react with?
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Alcohol causing nausea and cramps
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