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30 Cards in this Set

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How are Tetracyclines administered?
Orally; may be cheleated by calcium-containing products
How are Tetracyclines distributed?
wide distribution including saliva, breast milk, and transplacental distribution
What's the half-life for Tetracyline?
2 hours
How is Tetracycline concentrated (metabolized)?
Concentrated by the liver, excreted into the intestines via bile leading to enterohepatic circulation which prolongs activity
What are the forms of Tetracyclines?
doxycline and minocycline (later two excreted in urine)
What are the adverse reactions to Tetracyclines?
Primarily gastrointestinal
(anorexia, nausea, vomiting, diarrhea, stomatitis, xerostomia)
What are the superinfections for Tetracyclines?
Moniliasis and Psuedomembranous colitis
Where is another place Tetracyclines are concentrated?
In developing teeth and bones resulting in intrinsic staining (contraindicated in second half of pregnancy through age 8)
What are some damages that might occur with Tetracycline use?
Liver damage may result from IV use, kidney damage from outdated drugs, anemia, photosensivity, and vertigo
True or False.
Hypersensitivity to tetracyclines is unusual?
True
What are Tetracyclines antagonistic to?
other bacterial antiinfectives
What is the use for Tetracyclines dentally?
for periodontal infective agents
Tetracyclines are not indicated for?
Prophylactic use against B-E unless infective agent Aa

* We don't prescribe for patients with heart murmurs
What's a type of Clindamycin?
Cleosin
Tetracyclines are a bacteriostatic antibiotic against what?
gram+, some gram- and anaerobic Bateroides
Clindamycin interferes with?
Protein synthesis
How is Clindamycin administered?
Orally, topical, IM,IV
What's the half-life for clindamycin?
2.5 hours
Where is clindamycin metabolized?
In the liver, excreted in feces (bile) and urine
Clindamycin is anatagonistic to?
erythromycin by competing for same binding sites?
What are the adverse reactions to clindamycin?
GI (nausea, diarrhea, vomiting and pseudomembranous colitis)
What is are the superinfections for Clindamycin?
Monilia, allergy, low blood counts, some liver and kidney dysfunction
What is Clindamycin useful for?
Premed (pen allergy),and oral anaeorbic infections esp. perio

*treatment for periodontal disease
synthetic antiinfective, active against Trichomonas, amebicidal and bactericidal against obligate anaerobes
Metronidazole (Flagyl)
What does Metronidazole (Flagyl) destroy?
It destroys ring structure of DNA
What type of effect does Metronidazole (Flagyl) have?
Anti-inflammatory effect
What's the half-life for Metronidazole (Flagyl)?
8 hours
Where is Metronidazole (Flagyl) concentrated?
In crevicular fluid, less in the CSF, saliva and breast milk
What are some adverse effects for Metronidazole (Flagyl)?
GI, xerostomia, metallic taste, CNS, renal toxicity
What does Metronidazole (Flagyl) react with?
Alcohol causing nausea and cramps