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30 Cards in this Set
- Front
- Back
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fluoxetine, sertraline, or quinidine + CODEINE
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decreases effectiveness of codeine
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digoxin + quinidine, amiodarone or verapamil
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increases digoxin level by 25-100% and bradycardia
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Grapefruit juice + lovastatin, atorvastatin, or nifedipine
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increases lovastatin, atorvastatin, or nifedipine levels
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cyclosporine + rifampin or St. Johns Wort
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decreases cyclosporine levels
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cyclosporine + erythromycin or ketoconazole or diltiazem
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increases cyclosporine levels
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Warfarin + miconazole vaginal cream
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increased anticoagulation
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Propranolol + diltiazem or verapamil
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Additive bradycardia
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Theophylline + erythromycin or ciproflaxacin
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increases theophylline concentration;
decreases erythromycin concentration |
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albuterol + propranolol
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Decreases bronchodilation
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Sildenafil + nitrogylcerin or isosorbide dinitrate
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additive hypotension
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ciprofloxacin + Mg++, Fe++, Ca++, Zn++, Al+++
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decreases bioavailibility of ciprofloxacin
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oral contraceptives + antibiotics (many)
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decreases efficacy of oral contraceptives
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methotrexate + cotrimoxazole (Bactrim), NSAIDs or ASA
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increases methotrexate concentration
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oral contraceptives + smoking
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increases CV risk (MI, stroke, thrombeombolism) in pts > 35
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warfarin + rifampin
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decreases effectiveness of warfarin
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warfarin + cimetidine, cotrimoxazole, oxandrolone or amiodarone
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increases risk of bleeding
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warfarin + ASA or NSAIDS
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increases risk of bleeding
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Furosemide + NSAIDS
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decreases diuretic effects
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Rifampin or St.Johns Wort + nelfinavair, indinavir or ritonavir
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decreases serum concentrations of nelfinavair, ininavir or ritonavir (protease inhibitors)
decreased efficacy and increased chance of resistance |
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caffeine + ciprofloxacin
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increased caffine levels and effects
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clonidine + tricyclic antidepressants
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inhibits antihypertensive response to clonidine
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imipramine + epinephrine
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excessive increase in blood pressure
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allopurinol + azathioprine or 6-mercaptopurine
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increases toxicity of azathioprine; increased bioavailability
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Itraconazole or gemfibrozil + simvastatin or lovastatin
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reduced metabolism of the statins; increased myopathy
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cholestyramine or colestipol + pravastatin or fluvastatin
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reduced absorption of the statins
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MAO inhibitors + SSRIs
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serotonin syndrome
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MAO inhibitors + pseudoephedrine
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severe hypertension
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Potassium + ace inhibitors or spironolactone
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increases potassium levels
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thyroid hormone + Ca++ or raloxifene
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reduced absorbtion of thyroid hormone
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lithium + solium chloride
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lithium levels change inversely proportionally to sodium levels
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