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108 Cards in this Set

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AVenosine.

1 tx
2 diagnostics
1 MOA
1 opposing drug and class
Pharm. Adenosin first-line tx for SVT arrythmias requiring AV transduction (causes transient AV block). Also: dilates non-atherosclerotic coronary arteries; tests for atherosclerosis. MOA: hyperpolarizes cell (increased K out), preventing Ca++ influx. Opposes effect: Theophylline (a methylxanthine)
LFTs, PFTs, and TFTs; SAT for photo

1 tx
4 additional tox
Pharm. Amiodarone tox includes liver (abnormal LFTs and jaundice), lung (interstitial lung disease / pulmonary fibrosis), and thyroid pathology (drug resembles T4; can cause hypo- or hyperthryroidism). More tox: Blue/grey skin discoloration, photosensitivity (sulfonamides, amiodarone, tetracycline), corneal deposits, elevated QT. Tx: use when other antiarrhythmics fail.
The Queen ProclaimSLE Daiso's pyramid

Q 2 tox, P(K) 1 tox. 3 tx
Pharm. Class IA Na+ blockers include Quinidine (Tox: cinchonism = tinnitus and headache; increased QT = torsades), Procainamide (SLE-like syndrome), and Disopyramide. Tx: re-entrant and ectopic supraventricular arrhythmias and Vtach. Note: drugs that cause torsades include Class IA (Procainamide) and III
B is Best after ___.

2 tx
Pharm. Class IB Na+ blockers are best post-MI. Tx: acute ventricular arrhythmias and digitalis-induced arrhythmias.
I'd Buy Lidy's Mexican Tacos

2 tx
Pharm. Class IB Na+ blockers: Lidocaine, Mexiletine, Tocainide. Tx: acute ventricular arrhythmias and digitalis-induced arrhythmias. Preferentially targets ischemic and depolarized tissues.
C is Contraindicated after ___.

2 tx
2 tox
Pharm. Class IC Na+ blockers are contraindicated post-MI. Tx Vtach that progresses to Vfib, or intractable SVT. Pro-arrhythmic, especially post MI. Significantly prolongs AV refractory period.
Chipotle's Food has Excellent Produce

2 tx
2 tox
Pharm. Class IC Na+ blockers: Flecainide, Encainide, Propafenone. Tx: Vtach that progresses to Vfib, intractable SVT. Tox: pro-arrhythmic in MI, significantly prolongs AV refractory periods.
Dan's a Malignant, Hyper guy.

2 tx
Pharm. Dantrolene treats Malignant HTN (from inhaled anaesthetics and succynlcholine, depolarizing NMJ blockers) and Neuroleptic Malignant Syndrome. (antagonizes skeletal muscle SR Ca++ channel)
Ami, Bret, Duffy, and I But Sota

Ami extra MOA
1 Tx
Many tox (S2, I1, A8)
Pharm. K+ blockers: AMIodarone, BRETylium, Dofetilide, iBUTilide, SOTAlol. Tx: Use when other antiarrhythmics fail (increases ERP, AP duration, and QT interval). Amiodarone extra MOA: class 1, 2, 3, 4 effects because if its effect on the cell membrane. Sotolol: Torsades, beta blockade. Ibutilide: Torsades. Amiodarone: pulmonary fibrosis, elevated LFTs, hypo/hyperthyroidism (40% iodine, similar to T4), corneal deposits, blue/gray skin deposits resulting in photosensitivity, neurologic, constipation, CV effects (bradycardia, heartblock, CHF).
Please Try Not (being) Picky. Otherwise you may get lung disease or hypoglycemia!
Pharm. Nonselective beta antagonists include Propranolol, Timolol, Nadolol, (Beta blockers), and Pindolol, and are contraindicated in HTN pts with comorbid pulmonary disease because of bronchoconstriction. They may also cause "hypoglycemia unawareness" in diabetic patients.
At or any time

2 tox
Atorvastatin can be taken DAY or NIGHT. (Most statins must be taken at night because of nocturnal peak cholesterol synthesis) MOA: inhibits HMG CoA reductase (cholestrol sensor) in hepatocytes, causing increased LDL receptor expression. Tox: hepatotoxic (increased LFTs), rhabdomyolysis potentially leading to acute tubular necrosis (myoglobin is nephrotoxic; brown urine).
Brolactinoma; Same MOA: Pro- for 3 drugs

1 drug with same MOA and tx (C)
3 drugs with same MOA but fewer tx (PPR)
Tx PROlactinoma and Parkinsonism w/ BROmocriptine (MOA: DA analog) and cabergoline. Tx Parkinsonism: pERGOlide (ergot-derivative), Pramipexole, and Ropinerole. DA analogs can also tx Neuroleptic Malignant Syndrome in additional to Dantrolene (MOA skeletal muscle SR Ca++ blocker).
GROctreotide
Growth Hormone pituitary adenoma (Gigantism, Acromegally) tx Octreotide (somatostatin analog).
demecloSI(ADH)cline
Demeclocycline tx SIADH by inducing nephrogenic diabetes insipidis.
propylTHYROuracil

2 MOA
Propothiouracil tx Hyperthyroidism (Grave's). Blocks TPO iodine organification/coupling AND peripheral T3 to T4 conversion)
hit Diabetic debby in the Nuclear (PPAR-gamma) Sensitive -zone!
Drugs ending in -zone, such as Pioglitazone and Rosiglitazone, MOA increasing insulin sensitivity by GLUT-4 translocation in skeletal muscle and adipocytes.
Amide get Drunk, so I'll take the First taxi home.

1 drug class and MOA
First generation sulfonylureas (diabetes medication) end in -amide. Main tox: disulfiram-like reaction. MOA depolarizing beta-cells, inducing insulin secretions.
"GL" for GLyburide, GLimiperide, GLipizide, and hypoGLycemia
Second generation sulfonylureas start with GL, and their main tox is hypoglycemia. MOA depolarizes beta-cells, inducing insulin secretion.
liver HAVAc
Pharm. Drugs that have liver tox: Halothane, Acetamenophen, Valproic acid, Amanita phalloides.
brown pee, (H) OMG! no RBCs! Seek medical ATN!
Pharm. HMG CoA reductase inhibitor (statin) tox: Nephritis (Rhabdo). ATN: Acute Tubular Necrosis.
"C" for Corticosteroids; "C" for Cyclophosphamide; SLE rhymes with "C"
Pharm. Both corticosteroids and cyclophosphamide are immunosuppressive and 1st line tx for Lupus. Cyclophosphamide is a nitrogen mustard and DNA alkylating agent also used in chemotherapy regimes.
DA Bomb @ Halo
Pharm. Bromocriptine is a DA agonist (hyperprolactinemia tx), while Haloperidol is a DA antagonist.
Hemolysis IS PAIN
Pharm. Drugs that cause hemolysis in G6PD-deficient patients: Isoniazid (INH), Sulfa drugs, Primaquine, Aspirin, Ibuprofen, Nitrofurantoin.
12 BFs having a "blast" with PMS
Pharm. Drugs that cause megaloblastic anemia: Phenytoin, Methotrexate, Sulfa drugs. Other causes: B12 deficiency (diet [vegetarians] or pernicious anemia), folate deficiency).
EtanerCEPT is a cell reCEPTor decoy

2 tx
1 tox
1 similar drug (a monoclonal antibody)
Pharm. Etanercept is a TNF receptor decoy [hybrid IgG Fc region and TNF receptor) used to treat rheumatoid arthritis and ankylosing spondylitis. Tox: TB infection reactivation. Similar drug: infliximab.
Turn on the TuBe! I wanna watch netFlix!
Pharm. Infliximab can reactivate latent TB. MOA: anti-TNF Ab. Uses: ankylosing spondylitis. Tox: immunosuppression (reactivation of TB).
2 Molecules: Platelet-Gathering Inhibitor and Thromboxane A2
Pharm. PGI2 (COX2) inhibits platelet aggregation and promotes vasodilation; blocking PGI2 causes cardiac events). TxA2 (COX1) stimulates platelet aggregation. Aspirin inhibits COX1, reducing TXA2 levels and preventing platelet aggregation.
Have "you dined" with my "nuclear" family?
Pharm. -vudine antiretrovirals MOA: nucleosides inhibit HIV reverse transcriptase.
PEcK
Pharm. 1st generation cephalosporins (cefazolin, cephalexin) tx: gram + cocci and some gram negatives: (Proteus, E coli, and Klebsiella.)
HEN PEcKS
Pharm. 2nd generation cephalosporins (cefoxitin, cefaclor, cefuroxime) tx: gram positive cocci, H flu, Enterobacter, Neisseria spp., Proteus, E coli, Klebsiella, and Serratia.
"Mean" GNATS canNOT kill anaerobes

4 drugs
3 tox
Pharm. aMEANoglycosides include: Gentamicin, Neomycin, Amikacin, Tobramycin, Streptomycin. NOT = tox; nephro, oto, and teratogenic. Azithromycin is a macrolide, NOT an aminoglycoside. MOA blocks protein synthesis (30S ribosomal subunit).
Ceft I had a time for every time I got Pseudomonas, I could penetrate the BBB; TRI not to get gonorrhea

3 tx
Pharm. 3rd generation cephalosporins are for serious gram negative infections. Most cross BBB (meningitis). Ceftazidime tx Pseudomonas. Ceftriaxone tx gonorrhea.
With Imipenem, "the kill is LASTIN' with ciLASTATIN
Pharm. Cilastatin is normally administered with imipenem (MOA beta-lactam, inhibits transpeptidase), causing decreased renal inactivation of the antibiotic. MOA: inhibits renal dehydropeptidase. Meropenem is resistant to dehyrdopeptidase.
Man Got (ceftriax)owned!
Pharm. Meningitis and gonorrhea tx ceftraixone. Note: ceftazidime tx pseudomonas.
Ivermectin for rIVER blindness; BLACK skin, BLACK sign, ____fly

1 vector
1 parasite species/category
Pharm. River blindness: Onchocerca volvulus (female blackfly vector, nematode). MOA enhances inhibitory neurotransmission by activating glutamate-gated chloride channels (GluCls).
TMP Treats Marrow Poorly; USPS treats mail poorly

1 MOA
1 MOA for SMX
4 tx
Pharm. TMP tox: megaloblastic anemia, leukopenia, granulocytopenia. MOA dihydrofolate reductase inhibitor (prevents last step in folic acid synthesis). Folic acid is required for carrying carbons in purine synthesis. SMX MOA inhibits dihydropteroate synthetase (early step in folic acid synthesis). Tx: UTIs, Shigella, Pneumocystis pneumonia, Salmonella.
oh SN-AP! gram + filamentous rods!
Pharm. Tx. use Sulfa (TMP-SMX) for Nocardia; Actinomyces use Penicillin.
TMP Treats My Pee
Pharm. Uncomplicated UTI tx TMP-SMX (folate synthesis inhibitor). Metronidazole works for anaerobes and protozoans below the diaphragm, but it is not used for UTI.
Alen Bishop Donated for osteoporosis.

1 tox
Pharm. Alendronate (a bisphosphonate) tx for osteoporosis. MOA pyrophosphate analog, inhibits enzymes that utilize pyrophosphate --> osteoclasts). Worst tox: corrosive esophagitis
Beth Anne, call me if you want to activate yoru Bowels and Bladder
Pharm. Direct cholinomimetics (AChR agonist). Bethanechol tx for neurogenic ileus and urinary retention.
CARBon copy of ACh

1 tx
Pharm. Direct cholinomimetics. Carbachol is a direct cholinomimetic. Tx: glaucoma.
PILe on the Sweat and Tears!

1 additional tx
Pharm. Direct cholinomimetics. Pilocarpine is a potent stimulator of sweat, tear, and saliva secretion. Tx EMERGENCY GLAUCOMA.
Phys is for Eyes
Pharm. Indirect cholinomimetics (AChE inhibitors). Physostigmine crosses the BBB and can thus tx glaucoma.
NeO CNS

2 tx
Pharm. Indirect cholinomimetics (AChE inibitors). Neostigmine (tx m gravis, NMJ blockade) does NOt penetrate the CNS (can't be used to treat glaucoma).
Py for Peripheral

1 tx
Pharm. Indirect cholinomimetics (AChH inhibitors). Pyridostigmine doesn't cross the BBB; PNS only; no tx for glaucoma. Tx: myasthenia gravis. Note: pyridostigmine doesn't diagnose MG; Edrophonium does.
CAAPTOPRIL

3 tx
Note on bradykinin
Pharm. ACE-i tox: Cough (elevated bradykinin), Angioedema, Aldosterone inhibition (hyperkalemia), Proteinuria, Taste changes, hypOtension, Pregnancy problems, Rash / Renal tox (in bilateral renal stenosis). Tx hypertension, CHF, diabetic nephropathy.

Bradykinin is responsible for cough, vasodilation, permeability, and pain. ACE activations inactivates bradykinin; ACEi's cause an increase in bradykinin. Kallikrein activations bradykinin.
ACIDazolamide causes ACID___.

3 tx
3 tox
Pharm. Acetazolamide (CA inhibitor, induces diuresis of HCO3- by preventing its combination with H+) Tox: metabolic acidosis, sulfa allergy, ammonia toxicity. Tx HTN, Cystinuria (prevent Cysteine crystals by alkalinizing the urine), altitude sickness (induces metabolic acidosis to compensate for respiratory alkalosis).
D for Demeclocycline and Diuretic
Pharm. Demeclocycline, normally used as antibiotic tx for Borrelia, M Pneumo, Rocky Mtn SF, and Chlamydia, is also a diuretic (ADH antagonist, tx SIADH).
HyperGLUC

3 tx
4 + 3 tox
Pharm. Hydrochlorothiazide tox: hyperGlycemia, hyperLipidemia, hyperUricemia, and hyperCalcemia. Others: Hypokalemic metabolic alkalosis, hyponatremia, sulfa allergy. MOA: inhibits NaCl reabsorption in the early distal tubule. Use: HTN, CHF, idiopathic hypercalciuria.
Loops Lose calcium
Pharm. Loop diuretics cause hypocalcemia.
NAVIR TEASE a proTEASE. I said NEPHer, Crystal!
Pharm. MOA for -navir drugs: HIV protease inhibitors. Tox: crystal-induced nephropathy.
hydroCHLOROthiazide blocks what side of the NaCl cotransporter? Where??
Pharm. Thiazides bind to the CHLORIDE binding site of NaCl transporter on the early distal tubule, preventing salt reabsorption (tx HTN).
Cya @ ER
Pharm. Clomiphene is an ER antagonist on the hypothalamus. It causes a secondary increase in GnRH levels, inducing ovulation. Tx for anovulation.
Doxy-clean! So powerful it'll clean the enamel off your teeth!
Pharm. Drug tox (Category X) for doxycycline. Tooth staining, Enamel hypoplasia.
Play flute, no prostate.
Pharm. Flutamide is an androgen receptor antagonist. Tx: prostate cancer, gynecomastia.
LEMN drOP
Pharm. Lithium tox: Ebstein's anomaly, Movement (tremor), Nephrogenic diabetes insipidus, hypOthyroidism, Pregnancy problems.
Smoke acid N a Tube. Do acid to stop trippin!
Pharm. Valproic acid is an anti-epileptic drug that causes neural tube defects.
Quyen Met and Told Greasy Chlorplast Spores
Drugs that cause Disulfiram-like reaction (acute hangover sensation): Quinidine, Metronidazole, Tolbutamide, Griseofulvin, Chloramphenicol, and some Cephalosporins.
A for Aspirin and Asthma
Pharm. Aspirin tox: nasal polyps, asthma, and aspirin sensitivity (Samter's triad).
Queen Barb Steals Phen-phen and Refuses Greasy Carbs Chronically; RifAMPin AMPS up CYP 450! (as opposed to ritonavir).
Pharm. CYP450 inducers: Quinidine, Barbiturates, St. john's wort, Phenytoin, Rifampin, Griseofulvin, Carbamazepine, Chronic alcohol use.
It's not HIPP to have Lupus
Pharm. Drugs that cause a Lupus-like toxicity: Hydralazine, INH, Procainamide, Phenytoin.
Agranulocytosis Could Certainly Cause Pretty Major Damage
Pharm. Drugs that cause agranulocytosis (severe leukopenia): Clozapine, Carbamazapine, Colchicine, Propylthiouracil, Methimazole, Dapsone.
Some Drugs Create Awesome Knockers
Pharm. Drugs that cause gynecomastia include Spiro, Digitalis, Cimetidine, Alcohol, Ketoconazole
SAT for photo
Pharm. Drugs that cause photosensitivity: Sulfonamides, Amiodarone, Tetracyclines (Doxy).
bad rash after a PEC SLAPP; Stevens-Johnson is not phuny. It sux and is lamo.
Pharm. Drugs w/ Stevens-Johnson toxicity. Penicillin, Ethosuximide, Carbamazapine, Sulfa drugs, Lamotragine, Allopurinol, Phenytoin, Phenobarbital.
Qiss and qiq till you're siq of sqs; HAV 1 M&M; MAD 2's
Pharm. Monoamine receptors and their coupled G-protein receptors. alpha-1 (Gq), alpha-2 (Gi; inhibits sympathetic outflow), beta-1 (Gs; stimulates HR/contractility/BP[renin]), beta-2 (Gs; vasodilation/bronchodilation) [Alpha and Beta agonists are ALL SYMPATHOMIMETICS], [MUSCARINIC -> PANS) M1 (Gq; PANS to CNS/entericNS), M2 (Gi; decrease HR and contractility), M3 (Gq; secretions and sphincters), D1 (Gs), D2 (Gi), H1 (Gq), H2 (Gs; gastric acid), V1 (Gq; vasoconstriction), V2 (Gs; increases water permeability and resorption in the collecting ducts). ------- H1, alpha-1, vasopressin-1, M1 and M3 receptors are coupled to Gq. ------- M2, alpha-2, and D2 are coupled to Gi. (inhibitor = mad!).
Fish N' CHIPS Give you Myopathy
Pharm. Myopathy tox: Fibrates, Niacin, Colchicine, Hydroxychloroquine, Interferon alpha, Penicillamine, Statins, Glucocorticoids
NO! See the Gimp Man's Penis!
Pharm. NO and Sildafenil cause vasodilation through increased cGMP.
ISOproterenol is isolated to ___. not -lol!
Pharm. Sympathomimetics. Beta agonist (not blocker!!). Isolated to beta (1 = 2).
One Heart Two Lungs
The heart expresses beta-1, lungs express beta-2 adrenergic receptor.
Coz M3 (Gq) makes me pee! M2 (Gi) slows the heart, dude, M1 (Gq) motorway -- the northern route!
Muscarinic Receptor Song. Muscarinic receptors contract the BLADDER (M3), cause BRADYCARDIA (M2), and are widely expressed in the BRAIN (M1).
Tired Dopes Do Nada
Steps in Catecholamine synthesis: TYROSINE, DOPA, DOPAMINE, NE.
HiDe De HO
Enzymes in catecholamine synthesis: HYDROXYLASE, DECARBOXYLASE, Beta-OH-lase (hydroxylase).
Cytoplasm, COMT, Mitochondria, MAO
Enzymes of catecholamine metabolism
Constantly Aspiring to Phone Ethan
Drugs with zero-order kinetics: CONSTANT (zero-order), ASPIRIN, PHENYTOIN, ETHANOL
Curare, _ompetetive inhibitor.
Curare is a competetive nicotinic inhibitor.
GET GAP on the Metro!
Metronidazole tx Giardia, Entamoeba, Trichomonas, Gardnerella vaginalis, Anaerobes (B. fragilis, C. difficile), and H. pylori.
O negative MAGIC RACKS!
CYP 450 inhibitors: Omeprazole, Macrolides, Amiodarone, Grapefruit juice, Isoniazid, Cimetidine, Ritonavir, Acute alcohol abuse, Ciprofloxacin, Ketoconazole, Sulfonamides.
Dr Cline gave me a 50!
Clindamycin targets the 50S ribosomal subunit (protein synthesis inhibitor). Tox pseudomembranous colitis.
MACROlides and aminoglycosid3's
Macrolides (ex gentamicin) block the 50S ribosomal subunit. Aminoclycosid3s block the 30S subunit.
Amide local anasthetics have __ L's
2. Ex: Lidocaine, Bupivicaine, etc. Esters include tetracaine, benzocaine, procaine, cocaine. If patients have allergies to one class, the other class can still be used.
TNF alpha, B, KapoC; TNF Beta makes ___ Better; TNF Gamma tx ___; IL-2 tx 2 cancers: ___ and ____
TNF alpha tx chronic hep B, hep C, and Kaposi's sarcoma, TNF beta tx MS; TNF Gamma tx chronic Granulomatous dz; IL-2 tx RCC and metastatic melanoma.
Try to Fly High; T for Tainted reTina
High potency typical antipsychotics include Trifluoperazine, Fluphenazine, Haloperidol (tox extrapyramidal symptoms, aka parkinsonism, + neuroleptic malignant syndrome). Typical antipsychotic MOA DA antagonism (increase cAMP). Tx Schizophrenia + symptoms, Psychosis, acute mania, Tourette's. Trifluoperazine extra tox retinal pigmentation (vision loss)
Cheating Thieves are low; C for Corneal deposits
Low potency typical antopsychotics include Chlorpromazine and Thioridazine (tox non-neuro, including anticholinergic effects [ACh is PANS pre and post ganglionic, so anticholinergics are sympathetomimetics), antihistamine effects, and alpha blockade). Typical antipsychotic MOA DA antagonism, increase cAMP. Tx Schizophrenia + symptoms, psychosis, acute mania, Tourette's. Chlorpromazine extra tox corneal deposits.
it's Atypical for OLd CLOSets to QUIETly RISPER from A to Z; O for Obese. Watch Clozapine Clozely,
Atypical antipsychotics (MOA not fully understood; varying effects on serotonin, alpha adrenergic, histamine, DA receptors) include OLanzapine, CLOZapine, QUetiapine, RISPERadone, Aripiprazole, Ziprasidone. Tx Schizophrenia (+ and - symptoms). Olanzapine also tx OCD, anxiety, depression, Tourette's. Olanzapine extra tox weight gain. Clozapine extra tox agranulocytosis and seizures.
Tri-C's
Tricyclic antidepressants tox Convulsions (seizure), Coma, Cardiotoxicity (arrhythmia; antidote Bicarb infusion). Another C: antiCholinergic effects (dilated pupils, ileus, etc). Others: hyperpyrexia, respiratory depression).
PARK my M BENZ
Benztropin MOA muscarinic antagonist tx Parkinson's dz. Also tx dystonic reactions and extra-pyramidal signs.
IPRAy that I can breath soon!
Ipratropium MOA muscarinic antagonist tx Asthma, COPD.
TOMAs thumb is short; he Longs Friendship w/ the CDC
Short-acting benzos include Triazolam, Oxazepam, Midazolam, Alprazolam. Highest addictive potential, least side effects. Long-acting benzos include Flurazepam, Chlordiazepoxide, Diazepam, Clorazepate. Lowest addictive potential, most side effects.
MAO Takes Pride In Shanghai and has HTN
MAOi's include Tranylcypromine, Phenelzine, Isocarboxazid, Selegiline (selective MAO-B inhibitor. Tox: hypertensive crisis (NE release tox), exacerbated by ingestion of foods with tyramine (wine, cheese) and beta agonists.
thaLIMBomide
Thalidomide Catergory X tox: limb defects ("flipper" limbs).
Amean guy messed with a deaf baby
Aminoglycosides Category X tox: CN VIII (Vestibulocochlear) tox
Don't wage WARFare on the baby. Keep it HEPPY with HEParin.
Warfarin Category X tox: Bone abnormalities, fetal hemorrhage/abortion, ophthalmologic abnormalities. Use heparin on pregnant women instead.
FRENZodiazapines vs barbiDURATEs
Benzodiazapines MOA increase frequency of Cl- channel opening, facilitating GABA-A action. Barbiturates bind the same channel, but prolong the duration of Cl- channel opening.
pyRIDostigmine gets RID of ____, but you have to PHONE it in to diagnose!
Myasthenia gravis. Diagnostic: edrophonium. Similar MOA (AChE inhibitor), but shorter duration of action.
jesus ChRIST, BLAST that GREASY tax CHOLector, it's TAXing to stay polymerized
Vincristine (antineoplastic), Vinblastine (""), Griseofulvin (antifungal), Cholchicine (prevents gout), Paclitaxol (antineoplastic), and other Taxols are microtubule synthesis inhibition (except Paclitaxel: microtubule stabilization), interferes with mitotic spindle (M phase).
ACE those macrolide drug questions! ANGST of Aminoglycosides!
MACROlides (50S) include Azithromycin, Clarythromycin, Ezythromycin. Aminoglycosides include Neomycin, Gentamicin, Streptomycin, and Tobramycin.
ECSTaTiC about bacteriostatics; Very Finely Proficient At Cell Murder
Bacteriostatic: Erythromycin (a macrolide), Clindamycin (a lincosamide), SMX (antimetabolite), TMP (antimetabolite), Tetracyclines, Chloramphenicol. Bacteriocidal: Vancomycin, Fluoroquinolones, Penicillin, Aminoglycosides, Cephalosporins, Metronidazole
Buy AT 30, CCEL at 50
30S: Aminoglycosides, Tetracyclines
50S: Clindamycin, Chloramphenicol, Erythromycin (macrolides), Linezolid.
SAFE Moms Take Really Good Care
Antibiotics to avoid in pregnancy: SMX (kernicteris), Aminoglycosides (ototoxic), Fluoroquinolones (cartilage damage), Erythromycin (maternal acute cholecystitis; and clarythromycin = embryotoxic) Metronidazole (mutagen), Tetracycline (teeth and bone), Ribavirin (teratogen), Griseofulvin (teratogen), Chloramphenicol ("gray baby")
VACUUM THe BedRoom
Tetracyclines tx: Vibros cholerae, Acne, Chlamydia, Ureaplasma, Urealyticum, Mycoplasma, Tularemia, H pylori, Borellia, Rickettsia.
Zolin's Lexus won 1st
T for 3, except for the "foxy c"
4 letters in PIME
Cefazolin and Cephalexin are 1st generation Cephalosporins. CefTRIaxone, CefoTaxime, and CefTazidime are 3rd generation (covers Pseudamonas, but CeFOXiTin is 2nd generation. CefePIME is 4th generation (expanded Pseudamonas coverage)
Metformin deFORMS the kidney
Metformin tx DM2, MOA unknown (may decrease gluconeogenesis, increase glycolysis, increase insulin sensitivity), Tox lactic acidosis (contraindicated in renal failure)
SuccinylCurare

2 opposing drugs
NMJ blockers. Succinylcholine is depolarizing (tx overdose with cholinesterase inhibitors after acute phase), while tubocurarine, atracurium, mivacurium, pancuronium, vecuronium, and rocuronium are nondepolarizing (tx overdose with cholinesterase inhibitors (eg, neostigmine)
"C" for Cyclosporine, 'Crolimus, and Calcineurin
Cyclosporine and Tacrolimus MOA calcineurin inhibitors tx immunosuppression for organ transplantation. Calcineurin is required for IL-2 production (T-cell stimulation and maturation).
say BI 2 seizures
Drugs that cause seizures include Bupropion (MOA increased NE), Imipenem (beta-lactam antibiotic), INH (antimycobacterial).
HIV antivirals in chronological order:
Enfuvirtide : Entry
Have you dined with my nuclear family?
Never Ever Deliver nucleosides
Navir tease a proTEASE inhibitor
Enfuvirtide MOA fusion inhibitor (binds gp41). "Vudine" drugs MOA nucleoside RTI's. Non-Nucleoside RTI's include Nevirapine, Efavirenz, and Delavirdine. Protease inhibitors end in -navir (component of HAART along with RTI's).
Amantidine: "A man to dine" takes off his coat
Release Tammy!
Amantidine tx Influenza A, rubellA, PD, MOA inhibits viral uncoating (M2 protein), tox cerebellA.
OselTAMIvir and zanamivir MOA Influenza A/B neuraminidase inhibitor (prevents release of virus).