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50 Cards in this Set
- Front
- Back
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Parent RN always has a longer or shorter T1/2 than daughter?
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Longer
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In a generator the daughter should be easy to separate from the parent? T or F
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True
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The generator must always be?
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Sterile
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If the daughter is different RN than the parent it is considered?
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Carrier-free
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The generator should produce a granddaughter that is?
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stable or very-long half life
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2 types of generators
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Liquid
Solid column |
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Most common generator type in nuclear medicine
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Solid
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What determines if the generator is liquid or solid?
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The state of the parent RN when loaded into generator
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Components of a generator
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Eluting solvent
Tubing Column Adsorbant material Filter Lead case Elution |
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Name the 3 eluting solvents
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Normal saline
.9% NaCl Isotonic saline |
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What is the adsorbant material?
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Alumina (Al2O3)
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Where is the parent RN stored?
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On the adsorbant material found on the column
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Steps to elute 99mTc from generator
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Evacuated vial-> sucked through generator-> column-> filter-> elute vial
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What RN is created when eluting a Moly-> Tc generator?
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NaTcO4 or sodium pertechnetate
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What does the glass fritted disk (filter) filter out?
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Alumina
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How often must a Moly->Tc generator be eluted?
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every 23h
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NaTcO4 should be used within how many hours of elution?
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12h
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2 types of generator equilibrium
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Secular
Transient |
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Secular equilibrium
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parent has a half life greater than 100x daughter's
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parent has a half life 10-50x daughter's is called?
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Transient equilibrium
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How long does it take a Moly->Tc generator to reach equilibrium?
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24h
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Give an example of a transient equilibrium generator?
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Moly->Tc
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Formula for 99Mo efficiency
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(Amt of 99mTc produced/total activity of 99Mo) x 100
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Moly efficiency is about __%
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88%
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The yield of a generator is condisered the ___ ____?
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generator efficiency
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Moly->Tc generator efficiency is about __-___%
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85-95% (5-15% stays on the column)
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Amt of Moly loaded onto generator for hospitals? Pharmacy?
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.22-3Ci hospital
8.3-16.6Ci pharmacy |
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What must be listed on generator at time of calibration?
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Amt of 99Mo
Date & time calibrated Expiration date |
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Name advantages to using 99Mo generator?
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Gives Tc99m
No particles Daily elution can be labeled to many RP's Good half life High yield of 140kev photons |
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How many states of oxidation can Tc be found in? What are they?
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8 states
1- to 7+ |
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When electrons are transferred between 2 elements what state does this put it in?
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Oxidation
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Oxidation is the # of _____ compared to electrons
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protons
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When Tc is eluted what oxidation state is it found in?
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7+
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How is Tc reduced to other oxidation states?
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By labeling it in RP kit
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What common chemical is used to reduce Tc?
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Stannous Chloride
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Can Tc at 7+ be labeled?
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No
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What ratio of SnCl:Tc is required to reduce it?
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1million:1
10^6:1 |
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Most common oxidation states?
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7+,4+
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Why is free Tc bad?
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It is unbound and will not go to specified organs
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Common causes of free Tc
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--Tc not reduced (most common)
--O2 in vial --Not enough SnCl in kit |
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3 types of 99mTc in RP kit
Also known as radiochemical purity What is max allowable % |
Free
Bound Hydrolyzed 5% |
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What is hydrolyzed Tc
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Tc that has bonded to Tin
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Reasons Tc yield might be lower than expected
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Channeling
less Moly loaded than thought Clogged tubing Loss of vacuum Crack in elution vial |
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What is channeling?
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Pt of column not accesible to NaCl due to air bubble
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Difference of wet and dry generator
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Wet- leaves saline in after elution
Dry- drained after elution |
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Limit for Moly breakthrough
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0.15uCi Mo/Mci 99mTc
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Limit for Alumina breaththrough
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10ug Al/mL99mTc
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How is Moly breakhrough tested
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lead shield method
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How is alumina breakthrough tested?
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coloremetric method using a standard
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Eluant vs. Elution
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Eluant-what is loaded into generator
Elution-what comes out of generator |
