Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key


Play button


Play button




Click to flip

5 Cards in this Set

  • Front
  • Back
Age-Related Changes in Pharmacokinetics: Absorption, Distribution, Hepatic Metabolism, Renal Excretion
1. Absorption: no significant changes
2. Distribution: increased Vd lipophilic drug (increased fat), decreased Vd hydrophilic drug (decreased water), decreased binding acidic drugs/increased free drug (decreased albumin), increased binding of basic drugs (increased alpha-1-glycoprotein)
3. Hepatic Metabolism: decreased phase I reactions (build-up of active metabolites), no change in phase II reactions
4. Renal Excretion: reduced by 30-50%
Age-Related Changes in Pharmacodynamics: Increased Sensitivity, Decreased Sensitivity
1. Increased Sensitivity: sedative hypnotics, anticholinergics, analgesics, warfarin
2. Decreased Sensitivity: beta-adrenergic stimulants and blockers, alpha-adrenergic stimulants
Age-Related Changes in Adverse Drug Reactions: Increased Risk Factors, Unique Presentation
1. Increased Risk Factors: # of medications, comorbidities >6, Low BMI, age >85, impaired renal function
2. Unique Presentation: delerium, falls, fractures, urinary incontenence/retention, fecal incontenence/constipation, orthostatic hypotension, renal impairment
Is Adherence/Compliance to Medications Different in Elderly?
Adverse Effects in Neuroleptics: Sedation, Anticholinergic, Orthostasis, Extrapyramidal
1. Sedation: Olanzapine>Quetiapine>Resperidone
2. Anticholinergic: Olanzapine>Quetiapine
3. Orthostasis: Resperidone>Quetiapine
4. Extrapyramidal: Haloperidol>Resperidone