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20 Cards in this Set
- Front
- Back
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3 pain processes
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transduction
transmission modulation |
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nociceptor cell bodies are located in ___. they have low/high energy threshold and sense single/multiple energy modalities. receptive fields are constant/variable size across different body regions
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dorsal root ganglion
high multiple variable |
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first pain is carried by ___ fibers which are myelinated/non-myelinated.
signal travels at ___ m/s first pain is ___ |
Adelta
myelinated 1--35 sharp |
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second pain is carried by ___ fibers which are myelinated/non-myelinated.
signal travels at ___ m/s second pain is ___ |
C
non 0.3--1 dull |
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at synapse, nociceptor releases ___, which binds ___ receptor.
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substance P
NK |
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nocicpetors synapse in the ipsi/contralateral SC with ___. these ascend in SC via ___ tract to ___. decussation occurs at ___
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ipsilateral
projection neurons (WDR) lateral spinothalamic thalamus level of nociceptor SC entry |
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4 kinds of pain
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nociceptive
inflammatory neuropathic dysfunctional |
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4 kinds of dysfunctional pain
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migraine
tension headache fibromyalgia IBS |
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rubbing hand after hurting it causes pain relief because ___ neurons provide ___ input to ___s in the ___
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Abeta
inhibitory WDR neurons SC dorsal horn |
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descending regulation of pain occurs via ___ neurons in the ___ which synapse in ___ with ___ neurons. these neurons terminate in ____ of ___
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periaqueductal grey
midbrain medulla raphe nuclei dorsal horn SC |
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opiod receptors are present on afferent pre/post synaptic neurons
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yes
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inflammatory pain happens when ___ release ___ which ___
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leukocytes
inflammatory mediators lower nociceptor activation threshold |
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2' hyperalgesia is when ___ happens due to ___
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nociceptors outside inflamed region are hypersensitive
SC sensitization |
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T/F: post-op pain can be inflammatory
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true
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5 anti-inflammatory pain tx
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CS
NSAIDs free radical scavengers substance P blockers pain modulation |
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T/F: in neuropathic pain there is increased nociceptor sensitivity
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false
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in addition to ___ pain, in neuropathic pain there is ___
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spontaneous
loss of sensation |
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3 examples of neuropathic pain
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post mastectomy
post herpetic chronic constrictive injury |
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6 causes of neuropathic pain
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1' afferent sensitization
neurogenic inflammation central sensitization central reorganization sympathetically maintained loss of large fiber inhibition |
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primary afferents can be sensitized by ___. this causes ___s
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Na+ channel overexpression
ectopic discharge |
