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37 Cards in this Set
- Front
- Back
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What receptor does Baclofen (lioresal) act on?
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this is an AGONIST on GABAb
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How does Baclofen (lioresal) work?
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this hyperpolarizes and inhibits release of NT's from presynaptic terminals in the brian/spine
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While Baclofen (lioresal) can be given orally, what is the BEST way to dose this?
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intrathecal route
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How does diazepam (valium) work?
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this acts on GABAa in the spinal cord
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What does Diazepam (valium) treat?
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spasms associated with local muscle trauma
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What is the major side effect of Valium?
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sedation
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What receptor does Tizanidine (zanaflex) act on?
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this is an alpha-2 agonist, like clonidine
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what does Tizanidine (zanaflex) treat?
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this treats chronic muscle spasticity
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What does cyclobenzaprine (flexeril) do?
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this is a sedative at the brain stem level
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Other than sedative, what receptors does cyclobenzaprine act on?
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muscarinic- with anticholinergic activity
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What does cyclobenzaprine treat?
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acute muscle spasms
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What are the side effects of cyclobenzaprine?
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sedation, confusion, visual hallucinations
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How does Carisoprodol (Soma) work?
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this has a central sedative activity
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what are the CNS effects of Carisoprodoal (Soma)?
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this causes sedation, and altered pain perception
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What does Carisoprodal (soma) get metabolized to?
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meprobamate, which acts like a barbituates. HIGH ABUSE potential**
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How does Dantolene work?
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this interferes with release of calcium from the SR (doesnt affect CNS)
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other than muscle contractions, what does Dantrolene treat?
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malignant hyperthermia
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What drug treats neruoleptic malignant syndrome caused by antipsychotics?
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dantrolene
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What type of neurons does amphetamine strongly affect in the brain?
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Dopamine neurons
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How does Modafinil (provigil) work?
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this increases excitatory glutamine transmission in the thalamus and hippocampus
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Is provigil addicting?
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NO, its is 200 times less addictive than meth
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are there wirthdrawl symptoms from Modafinil?
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no there are not
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What enzymes does modafinil induce?
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this induces CYP3A4, which causes failure of oral contraceptives and cyclosproine
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What disease does methylphenidate and modafinil treat?
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Nacrolepsy!
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What is the root cause of ADHD?
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abnormal dopamine function fails to modulate GABAergic and glutaminergic neurons
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what is the basis for all ADHD treatments?
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theres all try to increase dopamine and NE
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How long does methyphenidate last?
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ritalin is short acting and needs to be given in the morning and at lunch
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How long does Pemoline (cylert) last?
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this is given once a day
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What kind of drug is Atomoxetine?
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this is a selective NE reuptake inhibitor
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Is there abuse potential with atomoxetine?
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No there is none
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Why was Phen-Fen withdrawn?
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this causes heart valve abnormalities
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Why was Sibutramine withdrawn?
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increased BP, increases heart attack and stroke risk
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What was dexfenfulramine withdrawn?
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this caused pulmonary hypertension
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how does caffeine work?
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this blocks adeonsine receptors, and increases cAMP by inhibiting phosphodiesterase
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What does caffiene inhibit?
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adenosine's action
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How does caffeine affect cerebral blood vessels?
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constricts them
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What does guarana do?
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this acts like caffiene, AND releases NE/DA
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