Pharmacology Winter Test 1 L1- Cns Intro

Front 1

What are ionotropic receptors? what two actions can they have?

Back 1

these are ligand gated ion channels

they can only depolarize (Na+), or hyperpolarize cells (Cl-)

Front 2

what are metabotropic receptors?

Back 2

these are coupled to G proteins

Front 3

What NT is involved in alzhemiers

Back 3

ACh

Front 4

What M type of receptor may be important in treating schizophrenia?

Back 4

M4

Front 5

Where are M2 receptors found in the brain?

Back 5

hippocampus and cortex, and are inhibitory

Front 6

Where are noradrenergic cell bodies found in the brain?

Back 6

locus coeruleus and reticular formation

Front 7

What does depletion of NE result in?

Back 7

depression

Front 8

what do alpha 1 receptors do?

Back 8

excitatory, increase IP3/DAG

Front 9

what do alpha 2 receptors do?

Back 9

inhibitory, decrease cAMP

Front 10

what do Beta 1 receptors do?

Back 10

Gs, increase cAMP

Front 11

What does cocaine do?

Back 11

inhibits NE re-uptake

Front 12

What does amphetamine do?

Back 12

this causes NE release

Front 13

What do antidepressants do that is similar to cocaine?

Back 13

they inhibit NE re-uptake

Front 14

What NT is affected in parkinsons disease?

Back 14

Dopamine

Front 15

What does too much dopamine cause?

Back 15

this causes schizophrenia

Front 16

What dopamine pathway plays a role in addiction?

Back 16

ventral tegmental area to the nucleus accumbens and prefrontal cortex

Front 17

What can altered serotonin activity be involved in?

Back 17

depression

Front 18

what does 5-HT promote (normally)

Back 18

sleep

Front 19

what does lack of 5-HT cause?

Back 19

anxiety

Front 20

What NT is involved in obsessive compulsive disorder?

Back 20

5-HT serotonin

Front 21

What does the 5-HT1a receptor do?

Back 21

inhibitory, increase K+ flow and hyperpolarization

Front 22

What does the 5-HT2a receptor do?

Back 22

excitatory, increases Ip3/dag

associated with schizophrenia

Front 23

What does the 5-HT3 receptor do?

Back 23

this is excitatory, ligand gated channel

associated with nausea

Front 24

What does the 5-HT4 receptor do?

Back 24

excitatory, decrease K conductance

Front 25

What is the major inhibitory amino acid NT?

Back 25

GABA

Front 26

Where do barbituates, benzodiazepines, and alcohol act? (what receptor)

Back 26

GABAa receptor

Front 27

How does enhancing GABA activity affect anxiety?

Back 27

this will relieve anxiety

Front 28

What is the GABAa receptor linked to?

Back 28

this is ionotropic, and increased CL- conductance

Front 29

What does GABAb receptor do? linked to?

Back 29

this is inhibitory, and decreased Ca2+ flow, or increases K+ flow

Front 30

What does baclofen do?

Back 30

this selectively activates GABA receptors- acts as an antispasmodic

Front 31

What is the major excitatory amino acid NT?

Back 31

Glutamate

Front 32

What do NMDA receptors respond to? and what do they do?

Back 32

this responds to glutamate,
increases Na+ and Ca2+ flow

Front 33

What do AMPA receptors respond to?

Back 33

these respond to Glutamate and increase conductance

Front 34

What does the Kainic acid receptor respond to?

Back 34

this responds to glutamate

Front 35

where are kinate receptors found?

Back 35

hippocampus, cerebellum, spinal cord

Front 36

What receptor type is important in memory and learning?

Back 36

NMDA receptor (which responds to glutamate, opens Ca2+)

Front 37

What kind of NT is glycine?

Back 37

this is an inhibitory NT found in the brain stem.
increases Cl- conductance

Front 38

What receptor type does strychnine affect?

Back 38

glycine receptors

Front 39

What does B endorphin stimulate?

Back 39

Mu receptor

Front 40

What does Enkephalin stimulate?

Back 40

delta receptor

Front 41

What does Dynorphin stimulate?

Back 41

kappa receptor

Front 42

What does TCH affect?

Back 42

cannabinoid receptor, which affect memory, cognitiion, pain perception, and modulates NT release