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29 Cards in this Set
- Front
- Back
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drugs ending in "pril"
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ACE inhbitors
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Ace inhibitor drug names end in
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"pril"
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What are effects of ACE of inhibitors?
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decrease BP, vasodilation
1. decrease afterload and preload -> decrease ventric hypetrophy = ventricular remodeling 2. decrease proteinuria in kidneys -> decrease Glom filt press -> prevent diabetic nephropathy |
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What are the different classes of Antihypertensives?
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ACE inhibiotors
Angiotensin II receptor blockers Alpha1 blockers Beta blockers Calcium channel blockers diuretics direct vasodilators? |
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example of ACE inhibitor?
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Captopril
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what is ventricular remodeling? What drug does this?
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prevention of progression of l. ventricle hyperplasia via lowering afterload and preload
ACE inhibotor |
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what is drug of choice for HF patients?
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ACE inhibitor - bc of ventricular remodeling
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What is an important drug in preventing diabetic nephropathy?
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ACE inhibtor - decrease proteinuria
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What are adverse effects of ACE inhibitors?
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first dose hypotension
hyperkalemia (affect of dec aldoesterone) NOT for preganant women, only if no safe alternative |
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T or F. Food should always be taken with ACE inhibitors.
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F. Food decreases absorpotion
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What antihypertensive is used for quick action?
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Captopril - ACE inhibitor
onset 15 min duration 2-6 hr |
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What are benefits of using Losartan instead of Captopril?
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Losartan (ARB) less likely to produce cough than Captopril (ACE inhibitor)
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how to counteract first dose hypotensive effects?
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give at bed time
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Example of alpha 1 antagonist? side effects?
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prazosin and doxazosin.
adverse effects - sodium retention - initial orthostasis --> give at bedtime |
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What effect do alpha 2 agonists have?
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alpha 2 receptors have inhibitory effects on alpha 1 = alpha1 blockers
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This drug inhibits relase of norepinephrine in brain
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Clonidine (alpha 2 agonist)
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these drugs end in "sartan"
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ARB - angiotensin II receptor blockers
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ARB's end in this
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"sartan"
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What is main precautions for ppl taking beta blockers?
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ppl with heart block (reduced conduction)
ppl with respiratory illness (bronchoconstriction) |
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exmaple of calcium channel blockers
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verapmil
amlodpine |
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What are the roles of calcium?
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1. induce contractions of smooth muscle
2. peripheral vasoconstriction 3. cardiac vasoconstriction |
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What are the effects and indications of calcium blocking agents?
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1. constipation
2. vasodilation,- Raynaud's, HTN, 3. increased cardiac perfusion, dec workload, dec contractility- angina 4. dec conduction of heart, dec HR - dysrhythmias |
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overall effects of Ca blocking
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vasodilation
reduced arterial pressure inc coronary perfusion |
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This durug is used in hypertensive emergencies
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Sodium Nitroprusside (vasodilator)
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What is Hydralazine
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VAsodilator - acts on vasc smooth muscle - peripheral
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What are precaustions for sodium nitroprusside?
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rapid drrops in BP --> constant montoring,
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This drug is a selective aldosterone blocker
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Eplerenone (vasodilator)
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What is contraindication for eplerenone
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a selective aldosterone blocker, so contra for
renal impairment high K |
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What drug inhibits action of CYP450?
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eplerenone (vasodilator)
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