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13 Cards in this Set

  • Front
  • Back
What causes migraines?
Something triggers the CNS to release neuropeptides from the trigeminovascular system leading to neurogenic inflammation and cranial vasodilation
Seven treatments to abort migraines. GO!
nonopioid analgesics
NSAIDs
COX-2 inhibitors
acetaminophen
triptans
ergot
antiemetics
Five prophylactics for migraines. GO GO!!
beta-blockers
antidepressants
anticonvulsants
Ca2+ channel blockers
opioids
When would you use a nonopioid analgesic?
for mild to moderate migraine with no nausea or vomiting
What NSAID is parenteral with a six hour duration?
ketorolac
What would you give with acetaminophen?
aspirin or caffeine
How do triptans work?
5HT 1B/1D agonists
1B receptor increases vasoconstriction
1D receptor inhibits peptide release and decreases inflammation
When are triptans contraindicated?
ischemic vasc, vasospastic heart, uncontrolled hypertension
What are the side effects of triptans?
tingling, heaviness, heat
Name some ergots.
ergotamine, dihydroergotamine
How do ergots work?
nonselective 5HT1 agonists
What are the side effects of ergots? When should they not be used?
overuse headaches, ergot poisoning, effects like oxytocin; don't use in coronary artery disease
Name two antiemetics used parenterally for migraines.
metoclopramide, prochlorperazine