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13 Cards in this Set
- Front
- Back
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What causes migraines?
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Something triggers the CNS to release neuropeptides from the trigeminovascular system leading to neurogenic inflammation and cranial vasodilation
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Seven treatments to abort migraines. GO!
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nonopioid analgesics
NSAIDs COX-2 inhibitors acetaminophen triptans ergot antiemetics |
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Five prophylactics for migraines. GO GO!!
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beta-blockers
antidepressants anticonvulsants Ca2+ channel blockers opioids |
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When would you use a nonopioid analgesic?
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for mild to moderate migraine with no nausea or vomiting
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What NSAID is parenteral with a six hour duration?
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ketorolac
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What would you give with acetaminophen?
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aspirin or caffeine
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How do triptans work?
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5HT 1B/1D agonists
1B receptor increases vasoconstriction 1D receptor inhibits peptide release and decreases inflammation |
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When are triptans contraindicated?
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ischemic vasc, vasospastic heart, uncontrolled hypertension
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What are the side effects of triptans?
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tingling, heaviness, heat
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Name some ergots.
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ergotamine, dihydroergotamine
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How do ergots work?
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nonselective 5HT1 agonists
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What are the side effects of ergots? When should they not be used?
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overuse headaches, ergot poisoning, effects like oxytocin; don't use in coronary artery disease
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Name two antiemetics used parenterally for migraines.
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metoclopramide, prochlorperazine
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