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6 Cards in this Set
- Front
- Back
Nicotine MOA?
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Nicotine binds alpha4 beta2 nicotinic Ach receptor in VTA releasing DA in NA
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Tolerence and tobacco?
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Up-regulation and desensitization of nAch receptors
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Nicotine Replacement therapies?
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Gum, patch, nasal spray, inhailer, lozenge
CI with recent MI, Severe angina and arrhythmias |
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Bupropion or Smoking?
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CI with seizures, bulimia, anorexia
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Varenicline?
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alpha4 beta2 partial agonist, in presence of nicotine, bllocks effects, can devlope mild physical dependence
CI: Pregnars, lactars, or kids |
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Pschiatric co-morbidities?
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Schizophrenia, MDD, dysthymia, bipolar, panic disorder, PTSD, ADHD, substance abuse
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