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12 Cards in this Set
- Front
- Back
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What is the general MOA of tetracyclines? What about their pharmacodynamic properties?
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They inhibit the 30S subunit. They are bacteriostatic agents.
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What is the MOR against tetracyclines?
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An efflux pump
Protector Protiens Enzymatic Inactivation |
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Describe the distribution of tetracyclines.
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They have a very wide distribution. They can enter synovial fluid, prostate, but, have minimal CSF penetration.
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Which tetracyclines are eliminated renally which are eliminated hepaticly?
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Renal: Tetracycline, Demecolcycline
Liver: Tigacycline, Minocycline, Doxycycline |
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What is the gram (+) coverage for tetracyclines?
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MSSA, PSSP, Group Strep, S. Viridans, Listeria, Bacilus, Nocardia
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What is the gram (-) coverage for tetracyclines?
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H. Pylori, H. Ducreyi, H. Influenzae, Camplobacter
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What is the atypical coverage for tetracyclines?
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Legionella, Chalymidia, Mycoplasma, Ureaplasma (pretty much last line for all)
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What are the contraindications for tetracyclines?
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Pregnancy
Kids Don't take with cations (like what other class?) |
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What are some of the side effects of tetracyclines?
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Photosensitivity, GI effects
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Which tetracycline is available PO?
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Doxycycline
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What is a predominant use for Tigacycline and Minocycline?
What can't these drugs fight? |
Mixed infections such as ulcers and abdominal infections.(it can attack MRSA)
They don't effect Pseudomonas or Proteus so you must cover these with another drug or rule them out. |
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List 4 tetracyclines.
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Tigacycline
Minocycline Doxycycline Democylocycline |
