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36 Cards in this Set
- Front
- Back
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What generation is cefazolin
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1st gen
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What generation is cephalexin monohydrate
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1st gen- oral
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What generation is cephradine
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1st gen
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What generation is Cefoxitin
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2nd gen
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What generation is cefamandole
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2nd gen
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What generation is cefaclor
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2nd gen- oral
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What generation is cefuroxime
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2nd gen
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What generation is cefprozil
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2nd gen- oral
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What generation is loracarbef
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2nd gen- oral
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What generation is cefotaxime sodium
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3rd gen
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What generation is cefoperazone
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3rd gen
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What generation is ceftazidime
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3rd gen
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What generation is ceftriaxone (rocephin)
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3rd gen
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What generation is cefixime
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3rd gen oral
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What is Cefepime (maxipime)
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a 4th gen cephalosporin given IV
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What do first generation cephalosporins have good activity against?
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G+ bacteria
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What gram + cocci do first generation cephalosproins NOT affect?
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enterococci, staph a, staph epidermis
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What specific 3 gram negatives do first generation cephalosproins have good activity against?
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E coli, Klebsiella pneumoniae, proteus mirabilis
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What are second generation cephalosprions used against?
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these have more G- coverage than 1st generation, but are far less active than 3rd generation
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What is special about cefotaxime sodium?
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3rd gen- CNS penetration
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What is special about Cefoperazone?
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3rd gen- Liver metabolism, antispeduomonal
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What is special about ceftazidime?
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3rd gen- antipseudomonal
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What is special about ceftriaxone?
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CNS penetration, hepatic elimination
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What four bugs do cephalosproins (any gen) NOT work well against?
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MRSA
Enterococci Listeria Atypicals (chlamydia, mycoplasma) |
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How do cephalosproins work?
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these interfere with bacterial cell wall synthesis
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Where in the body do cephalosorins generally NOT penetrate?
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the eye and CNS
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What generation of cephalosporins DO penetrate the CNS?
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3rd gen, specifically Cefixime*
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What is the ONLY cephalosporin that is metabolized by the liver?
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Ceftriaxone (rocephan)
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What drug can be given to prolong cephalosporin's half life?
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Probenecid
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What is the major excretion method of cephalosporins?
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renal, so be sure to adjust dosage with renal impariment
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What are the major adverse reactions of cephalosporins?
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pesudomembranous colitis
super infection disulfram-like effect with booze + coombs test Severe diarrhea renal tubular necrosis nephrotoxicity with aminoglycosides |
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do cephalosproins and penicillin cross react?
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cephalosporins can be tolerated in people with penicillin allergies
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What is Cefepime?
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this is a 4th generation cephalosporin, given IV only
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What bugs does Cefepime cover?
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both G+ and G- and pseudomonas aeruginosa
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Does Cefepime penetrate the CNS?
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yes it does
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Are there any major side effects of Cefepime?
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no there are not
but it can alter lab values |
