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38 Cards in this Set
- Front
- Back
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What is the most common form of malaria?
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P Vivax
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What is the presentation of P. malariae infection?
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fever every fourth day
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What do blood schizonticides affect?
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these eliminate parasite from erythrocyte
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do blood schizonticides get the secondary tissue forms?
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no they dont
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What do tissue schizonticides do?
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eliminate bugs from tissues, acting on hepatic stages
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What stage of bugs do tissue schizonticides kill?
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the secondary tissue forms, aka cryptozoites
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What do Gametocidal agents do?
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these eliminate proliferation, and slow the spread of disease
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What type of agent is Chloroquine?
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this is a blood schizonticide
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what forms does Chloroquine treat?
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clinical cure for all forms
radical cure for falciparum and malariea |
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What is the DOC for blood schizoniticide sensitive organisms?
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Chloroquine
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How is there resistance to Chloroquine?
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pump it out of the parasite
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how is Chloroquine given?
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orally
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What inhibits Chloroquine absorption?
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Mg2+ and Ca2+ antacides
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What happens if you give Chloroquine too fast?
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cardiac arrest
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Who should not get Chloroquine?
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people with psoriasis and porphyria
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what is Chloroquine method of action?
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interferes with plasmodial digestion of hemaglobin
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What forms of malaria does Quinine effect?
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erythrocytic forms
and gametocidal with vivax/malariae |
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What is the DOC for complicated chloroquine resistant plasmodia?
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Quinine
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How is Quinine given?
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IV
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What are the toxic effects of Quinine?
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Cinchonism- tinnitus, HA, dizziness, flushing, visual disturbances
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What are the toxic effects of quinine?
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increase uterine contractions
blackwater fever skeletal muscle relaxation |
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What is the DOC for complicated choloquine-resistant malaria?
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Doxy+ quinindine gluconate
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What is the DOC for prophylaxis of malaria?
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Mefloquine
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What stage of of malaria does Mefloquine act on?
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erythrocytic forms
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How is mefloquine given?
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orally only
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Who should NOT get Mefloquine?
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people with a Hx of mental illness or epilepsy
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What are the adverse effects of Mefloquine?
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GI upset
neruo- seizures, psychosis, sleep disturbances |
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What is the method of action for sulfadoxine?
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inhibits incorporation of PABA into folic acid
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What is the method of action for Pyrimethamine and proguanil?
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inhibit dihydrofolate reductase, prevents THF formation
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What is the DOC for uncomplicated chloroquine resistant malaria?
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Atovaquone+ Proguanil
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What does Atovaquone do?
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this interferes with mitochondrial function in plasmodia
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What is Halofantrine?
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this used for drug resistant strains of falciparum/vivax
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What is Primaquine used for?
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radical cures of vivax/ovale
terminal prophylaxis |
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What is the contraindication to primaquine?
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G6PD deficiency
teratogenic |
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What is the DOC for chlorquine sensitive plasmodia?
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chloroquine- duh
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What is the DOC for chloroquine rsistant falciparum?
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atovaquone with proguanil
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What is the DOC for chloroquine-resistant vivax?
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Quinine sulfat plus doxycycline
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What is the DOC for severe malaria?
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Quinidine+ Doxy/clindamycin/tetracycline
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