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33 Cards in this Set

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  • Back
Name a brand of ribavirin?
Virazole
manufactured by ICN Pharmaceuticals, Inc
Name a therapeutic classification of ribavirin?
antiviral
Name a pharmacologic classification of ribavirin?
nucleoside analogues
What is ribavirin used for?
treatment for RSV
At the first sign of illness, physicians can test for RSV infection using?
rapid diagnostic test
Early and aggressive treatment with an ______ has been proven to decrease the morbidity associated with RSV in high-risk young children
antiviral
Ribavirin by _____ is the only antiviral agent approved for treatment of severe RSV disease in infants and children
aerosol
Virazole is a broad-spectrum antiviral with virustatic effects, inhibiting ____ _____ during the active replication phase.
RSV replication
Virazole greatly improves what 3 things?
hint: oxygenation?
illness?
viral shedding?
arterial blood oxygenation
decreases illness severity
decreases viral shedding
Virazole achieves maximum antiviral effect before the viral load is at its _____.

3 days
peak...this is usually within how many days of onset of symptoms?
What are the most common adverse events attributed to Virazole given to infants?
rash
reversible skin irritation
Sudden deterioration of respiratory function (bronchospasm) has been associated with initiation of aerosolized Virazole in?
infants...monitor carefully
Administration of Virazole is confined strictly to the_______ _______ and is delivered via a small particle aerosol generator known as a?
hospital setting

SPAG-2
Virazole aerosol is NOT to be administered with another aerosol-generating device or together with other?
aerosolized meds
The aerosol is delivered to the patient through an (3) attached to the generator.
oxygen hood or
oxygen tent or
face mask
The use of aerosolized Virazole in patients requiring _______ _______ assistance should be undertaken only by physicians and support staff familiar with the specific ventilator being used and this mode of administration of the drug.
mechanical ventilator
The feature:
improves O2 sat?
accelerates patient recovery with fewer supplemental O2 requirements
The feature:
reduces viral shedding?
reduces risk of nosocomial spread and therefore decreases possible morbidity/mortality in other patients
Strict attention must be paid to procedures that have been shown to minimize the accumulation of drug ____, which can result in mechanical ventilator dysfunction and associated increased ______ ________.
precipitate

pulmonary pressures
The standard treatment regimen is ____ given ____ to ____ ____ per day for 3 to 7 days.
20

12 to 18 hrs
It is important to note that Virazole is part of a total treatment program that includes? (3)
standard supportive
respiratory care
correction of fluid imbalance
nutritional management
The recommendd dosage regimen for those who require mechanical ventilation is the same as for those?
who do not
Either a pressure or _____-_____ ventilator may be used in conjunction with the SPAG-2.
volume-cycle
Because Virazole is administered as an aerosol, what should the hcp avoid or minimize contact with?
direct exposure to aerosol...remain cautious of exposure
Virazole should be administeed in well-ventilated roms and the SPAG unit should be turned off how many minutes prior to patient handling?
5 to 10
As an additional precaution, the use of a mask designed to block absorption of particles less than 1 micron in diameter is sugggested, and _____ ____ should be advised to avoid contact with Virazole
pregnant women
Adverse events with use of Virazole are?
headache (51%)
conjunctivitis (32%)
rhinitis, nausea, rash,
dizziness, pharyngitis, and
lacrimation (10-20% each)
Patients with RAD (underlying reactive airway disease) have reportedly suffered from what conditions?
bronchospasm
and/or
chest pain
Most adverse events have resolved within?
minutes after discontinuing exposure to aerosolized Virazole...it is unknown wheter these symptoms were due to drug exposure or RSV infection
At dosage levels exceeding human therapeutic levels, Virazole has been shown to produce what in rodents?
testicular lesions...and teratogenic in animal species in which adequate studies have been conducted
Davis...assess vital signs and chest pain...may cause?
MI
Assess patients for signs of colitis...which are?
abdominal pain
bloody diarrhea
fever

d/c...may be fatal
Assess patients for signs of pancreatitis...which are?
nausea
vomiting
abdominal pain

d/c...may be fatal