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26 Cards in this Set
- Front
- Back
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Adverse effects
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undesired effects of a drug that may be harmful and require reduction in dose or discontinuation of the preparation.
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Agonist
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a drug that binds to a receptor to produce an effect.
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Antagonist
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a drug that binds to a specific receptor to block the action of a chemical body substance or agonist drug from binding to the receptor.
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Contraindications
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conditions, diseases, situations, or patients where use of a drug is not indicated
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Dose
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exact amount of a drug that is administered to produce a specific effect
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dose response curve
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condition or disease for which a drug is given
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mechanism of action
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explanation of how a drug produces its intended therapeautic effect
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pharmacokinetics
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study of the process of drug absorption, disruption, metabolism, and excretion
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potency
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the power of strength of a drug at a specified concentration
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receptor site
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the specific location on the cell membrane where a drug binds to form a drug-receptor complex
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side effects
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effect of a drug other than the therapeutic effect.
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site of action
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place in the body where a drug produces a desired therapeutic effect
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therapeutic effect
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the desired medicinal effect of a drug
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time-response curve
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mathematical curve that plots the effect of a particular drug dosage over time
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toxic effects
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undesired effects that produce serious toxicity that usually lead to discontinuation of the drug and alternative therapy
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Chemical name
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specific chemical description of a drug
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generic name
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non proprietary name, often a shortened version of the chemical name
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trade name
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proprietary name, name assigned by the pharmaceutical company marketing a drug
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ED50
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effective dose 50 - does that will produce half of the maximal drug response, determined from a dose -response curve
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LD50
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lethal dose 50 - dose of a drug that will kill 50% of test animals. it is determined from a lethal dose-response curve.
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TI
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therapeutic index - ratio of the LD50 to the ED50, used to predict drug safety
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bioavailability
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percentage of a drug dose that is absorbed
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drug absorption
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entrance of a drug into the bloodstream from its site of administration
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drug distribution
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passage of a drug from the blood to the tissues of the body
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drug metabolism
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biotransformation - the chemical alteration of a drug in the body. often occurs prior to excretion of a drug.
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drug exrcretion
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process by whice substances, including drugs, are removed from the body.
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