Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
11 Cards in this Set
- Front
- Back
|
What are the classifications of psychotomimetic drugs? Give Examples of each class.
|
indoleamines (related to 5HT): LSD, Psilocin, DMT (synthetic 5HT derivative), butofenon (plant extract & toads)
phenylethylamines: mescaline (peyote), MDMA (Ecstasy—amphetamine like), PCP (Phencylcidine) anticholinergics: atropine, scopolamine cannibinoids: tetrahydrocannibinol (THC) amphetamines cocaine EtOH |
|
|
What is LSD-25 (Lysergic Acid Diethylamide)? What is its classification? What are its effects? How are its effects reversed? What are the chronic effects of its use?
|
5HT2 agonist and DA effects
Psychotomimetic indole (related to serotonin) similar structure to oxytocic ergonovine Orally active Setting-specific variable results+ distortion of reality, short term memory, panic states. Hi dose autonomic activation+ psychopharmacologic effects reversed by neuroleptics Chronic effects – tolerance, flashbacks |
|
|
What are the effects of Marijuana ( active ingredient is THC)? What are the side effects? What are its clinical uses?
|
Euphoriant, altered perception of time and space
SE – red eyes, cough, lung carcinogens, & other controversial effects antiemetic: medical marijuana for nausea, glaucoma, etc. |
|
|
What is Anandamide? What is kind of receptor does it act at?
|
Endogenous ligand for the THC receptor abundant G-protein coupled receptor
|
|
|
What is Rimonabant? What is it used for?
|
cannabinoid receptor CB1.
selective antagonist (obesity & smoking cessation). |
|
|
What is 3,4-methylenedioxymetamphetamine (MDMA) aka Ecstasy? What is its mechanism of action? What does a high dose cause? What are some side effects?
|
amphetamine-like hallucinogen
Indirect 5HT agonist+ looks structurally like DA Milder hallucinogen than LSD – euphoric Hi dose neurotoxicity to 5HT neurons other SE: hyperthermia, HT, teeth grinding, jaw clenching, clouded thinking |
|
|
What is mescaline aka Peyote? What are its effects?
|
phenylethylamine psychotomimetic
Similar pharm effects to LSD (which is an indoleamine) |
|
|
What is Phencyclidine (Sernyl) aka PCP, Hog, or Angel Dust? What was it originally designed to do? What are the effects of its use?
|
Noncompetitive NMDA antagonist
phenylethylamine psychotomimetic IV anesthetic design+ pts had emergent psychomimetic effects Drug of abuse, speed high, paranoid schizo in some Minority of people experience duration of action far beyond drug’s presence in the body effects: nystagmus, euphoria, depersonalization, hallucinations (high dose), muscle weakness (in contrast to anecdotal tales of aggressive superstrong people on PCP) |
|
|
What are central effects of the the anticholinergics atropine, scopolamine?
|
Centrally acting can produce psychosis, delirium that worsens with neuroleptic treatment (so Haldol good for delirium except from anticholinergic toxidrome—"dry as a bone, red as a beet, mad as a hatter, ...")
|
|
|
What class is psilocin, psilocybin? What are the effects? What is the mechanism of action? Where can you get some?
|
Indole, similar effects to LSD, cross-tolerance
5HT2 agonists Active alkaloids of hallucinogenic mushrooms Same ring structure as 5HT |
|
|
What is Salvia divinorum? What are the effects? What is the mechanism?
|
hallucinogenic plant from Central America. Brief, intense psychotomimeitc experience+ currently legal and available. The active ingredient (salvinorum) is a selective, highly potent kappa opioid receptor agonist
|
