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7 Cards in this Set
- Front
- Back
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What properties of certain drugs allow them to passively diffuse across lipid membranes?
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They are non-ionized (HA) and and lipophilic
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In what form (ionized or non-ionized) and at what pH (low or high) of weak acids allow them to pass at a faster rate across the lipid membrane?
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Non-ionized form, low pH
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Weak acids typically take the form of what compound?
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Salts, an example is aspirin
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In what form (ionized or non-ionized) and at what pH (low or high) or weak bases allow them to pass at a faster rate across the lipid membrane?
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Non-ionized form, high pH
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Where are weak acids more readily absorbed?
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Stomach, because the pH is lower
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Where are the weak bases more readily absorbed?
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Intestine, because the pH is higher
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What is the definition of "ion trapping"?
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Weakly acidic or basic drugs may tend to concentrate (i.e. become "trapped") on one side of a membrane when the pHs of the fluids on either side are different
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