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7 Cards in this Set

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What properties of certain drugs allow them to passively diffuse across lipid membranes?
They are non-ionized (HA) and and lipophilic
In what form (ionized or non-ionized) and at what pH (low or high) of weak acids allow them to pass at a faster rate across the lipid membrane?
Non-ionized form, low pH
Weak acids typically take the form of what compound?
Salts, an example is aspirin
In what form (ionized or non-ionized) and at what pH (low or high) or weak bases allow them to pass at a faster rate across the lipid membrane?
Non-ionized form, high pH
Where are weak acids more readily absorbed?
Stomach, because the pH is lower
Where are the weak bases more readily absorbed?
Intestine, because the pH is higher
What is the definition of "ion trapping"?
Weakly acidic or basic drugs may tend to concentrate (i.e. become "trapped") on one side of a membrane when the pHs of the fluids on either side are different