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29 Cards in this Set
- Front
- Back
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Phenylephrine (Neosynephrine)
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direct acting alpha 1 agonist
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isoproterenol (isuprel)
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direct acting beta 1 and beta 2 agonist
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alpha methyl tyrosine
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competitive inhibitor of tyrosine hydroxylase--blocks sythesis of DOPA and therefore decreases release of NE
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pheocromocytoma
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tumor of the adrenal medulla
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tyrosine hydroxylase converts alpha methyl tyrosine to
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alpha methyl norepinephrine--alpha 2 agonist
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reserpine
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inhibits the transporter that transports NE inside the vesicle (VMAT)--prevents storage of NE and therefore decreases NE release
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guanethidine
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taken up by nerve terminal by reuptake mechanism
blocks fusion of synaptic vesicle with cell membrane prevents NE release |
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clonidine (alpha methyl norepinephrine)
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presynaptic alpha 2 receptor agonist--decreases the release of NE
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product of MAO acting on epinephrine
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dihyroxymandelic acid
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product of COMT acting on dihydroxymandelic acid
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VMA (vanillylmandelic acid)
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product of COMT acting on epinephrine
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metanephrine
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product of MAO acting on metanephrine
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VMA (vanillylmandelic acid)
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product of MAO acting on NE
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dihydroxymandelic acid
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product of COMT acting on dihydroxymandelic acid
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VMA (vanillylmandelic acid)
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product of MAO acting on normetanephrine
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VMA (vanillylmandelic acid)
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product of MAO acting on dopamine
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dihydroxyphenylacetic acid
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product of COMT acting on dopamine
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3-methoxytyramine
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product of COMT acting on dihydroxyphenylacetic acid
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homovanillic acid
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product of MAO acting on 3-methoxytyramine
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homovanillic acid
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What is the clinical use for drugs that decrease NE levels?
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treats hypertension
decreased NE--> less alpha 1 activation in the arterioles-->decreased TPR-->decreased BP |
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Imipramine
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blocks the reuptake of NE into the nerve terminal-->more NE in the CNS
increased attention and alertness less depression treats enuresis (peripheral effect) |
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desipramine
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inhibits NE reuptake
antidepressant |
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cocaine
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decreased reuptake of NE, DA, serotonin
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phenelzine
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MAO inhibitor
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drugs that release NE from cytoplasmic pools or synaptic vesicles
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amphetamines
tyramine |
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adrenergic alpha 1 receptor activation
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constriction of smooth muscle
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alpha 1 receptor location
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arterioles, eye, nose, skin, gut and brain
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phenylephrine
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alpha 1 receptor
eye drop--mydriatic agent (dialysis) nasal spray: nasal decongestant |
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pseudoephredrine (sudafed)
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alpha 1 agonist
sympathetic side effects: increased BP, difficulty urinating, etc. |
