Pharmacology Of Dopaminergic Neurotransmission

Front 1

drug used for parkinson's disease

side effects: dyskinesia, heart disease, orthostatic hypotension, psychotic disorder, loss of appetite, nausea, vomiting

contraindications: history of melanoma, narrow angle glaucoma, concomitant use of MAO inhibitor

Back 1

Levodopa

Front 2

drug used for Parkinson's disease and restless leg syndrome (r)

side effects: dyskinesia, orthostatic hypotension, extrapyramidal movements, somnolence, dizziness, hallucinations, dream disorder, asthenia, amnesia

contraindications: concomitant use of other sedating medications

Back 2

pramipexole and ropinirole

Front 3

drug used for Parkinson's disease that inhibits levodopa/dopamine metabolism

side effects: bundle branch block, GI hemorrhage, orthostatic hypotension, dyskinesia, rash, dyspepsia, arthralgia, headache, weight loss, insomnia (s), confusion (s)

contraindications: concomitant use of cyclobenzaprine, mirtazapine, St. John's wort, dextromethorphan, meperidine, methadone, propoxyphene, tramadol, other MAO inhibitors or sympathomimetic amines, cocaine/local anesthesia containing vasoconstrictors; elective surgery requiring general anesthesia, pheochromocytoma

Back 3

Rasagiline and Selegiline

Front 4

inhibitors(COMT) of levodopa or dopamine metabolism used for Parkinson's disease

side effects: dyskinesia, dystonia, hallucinations, orthostatic hypotension (t), hyperpyrexia (t), fulminant hepatic failure (t), rhabdomyolysis (t), dyspepsia, dream disorder, sleep disorder

contraindications: history of rhabdomyolysis or hyperpyrexia; liver disease

Back 4

tolcapone and entacapone

Front 5

drug used for Parkinson's disease and Influenza A

side effects: Neuroleptic malignant syndrome, exacerbation of mental disorder, insomnia, dizziness, hallucinations, agitation, orthostatic hypotension, peripheral edema, dyspepsia, livedo reticularis

Back 5

Amantidine

Front 6

drug used for Parkinson's disease

side effects: angle closure glaucoma, increased intraocular pressure, psychosis, hyperpyrexia (b), paralytic ileus(b); dizziness, blurred vision, nervousness, nausea, xerostomia, urinary retention

contraindications: narrow angle glaucoma, younger than 3 years, tardive dyskinesis

Back 6

trihexyphenidyl and benztropine

Front 7

drugs used for psychotic disorder, nausea and vomiting (c adn p)

side effects: parkinsonian symptoms, neuroleptic malignant syndrome, tardive dyskinesias, anticholinergic symptoms, orthostatic hypotension, failure to ejaculate, sedation

contraindications: myelosuppression, severe toxic CNS depression/comatose state, concomitant administration of drugs that prolong QT interval or patients with prolonged QT interval (t adn m), parkinson's disease

Back 7

Phenothiazines adn derivatives: chlorpromazine, thioridazine, mesoridazine, perphenazine, fluphenazine, thiothixene, trifluoperazine, chlorprothixene

Front 8

drug used for psychoses (h), Tourettes syndrome (h), Nausea and vomiting, anesthesia adjunct (d)

side effects: parkinsonian symptoms, neuroleptic malignant syndrome, tardive dyskinesias, anticholinergic symptoms, orthostatic hypotension, failure to ejaculate, sedation

contraindications: Parkinson's disease, severe toxic CNS depression/comatose state

Back 8

Butyrophenones: haloperidol and droperidol

Front 9

drugs used for psychotic disorders adn tourettes syndrome

side effects: parkinsonian symptoms, neuroleptic malignant syndrome, tardive dyskinesia, prolonged QT interval (p), anticholinergic symptoms, sedation

contraindications: comatose or severe drug-induced depressed states, parkinson's disease; P: concomitant use of pemoline, methylphenidate, amphetamines, dofetilide, sotalol, quinidine, Ia and III antiarrhythmics, mesoridazine, thioridazine, chlorpromazine, droperidol, spargloxacin, gatifloxacin, moxifloxacin, halofantrine, mefloquine, pentamidine, arsenic trioxide, levomethadyl acetate, dolasetron mesylate, probucol, tacrolimus, ziprasidone, sertraline, macrolides, QT prolongation, inhibitors P450 3A4, cardiac arrhythmias

Back 9

loxapine, molindone, pimozide

Front 10

drug used for psychotic disorders and bipolar disorders

side effects: mild extrapyramidal symptoms, QT prolongation, anticholinergic symptoms, sedation, weight gain

Back 10

risperidone

Front 11

drug used for schizophrenia refractory to other antipsychotics

side effects: mild extrapyramidal symptoms, QT prolongation, anticholinergic symptoms (dry mouth, constipation, urinary retention), sedation, weight gain

contraindications: history of agranulocytosis or severe granulocytopenia, myeloproliferative disorders

Back 11

clozapine

Front 12

drug used for psychotic disorders and bipolar disorder

side effects: mild extrapyramidal symptoms, sedation, weight gain

binds D1-D4, 5-HT2, alpha 1, H1, M1-M5

Back 12

olanzapine

Front 13

drug used for psychotic disorders and bipolar disorder

side effects: mild extrapyramidal symptoms, anticholinergic symptoms, sedation, weight gain

****binds D1, D2, 5-HT2, 5-HT1, alpha1 and 2, H1

Back 13

Quetiapine

Front 14

drug used for psychotic disorder and bipolar disorder

side effects: mild extrapyramidal symptoms, QT prolongation, anticholinergic symptoms, sedation, weight gain

contraindications: concomitant arsenic trioxide, chlorpromazine, Clase Ia adn II anti arrhythmics, drugs that cause QT prolongation, mesorridazine, moxifloxacin, pentamidine, pimozide, probucol, sotalol, sparfloxacin, tacrolimus, thioridazine; cardiac arrhythmia, recent MI, uncompensated heart failure

Binds: D2, 5-HT1, 5-HT2, alpha 1, H1

Back 14

ziprasidone

Front 15

drug used for psychotic disorders and bipolar disorder

side effects: mild extrapyramidal symptoms, QT prolongation, anticholinergic symptoms, sedation, weight gain

D2 and 5-HT1A partial agonist and 5-HT2A antagonist

Back 15

aripiprazole