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7 Cards in this Set
- Front
- Back
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B2 Adrenoceptor agonists |
Salbutamol, Salmeterol increase cAMP, which leadsto bronchodilation and possible effects on mast cells. |
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Methylxanthines |
Theophylline phosphodiesteraseinhibitor, this prevents the conversion of cAMP to AMP, thus there is amaintained increase in cAMP, which leads to increased PKA and increasedbronchodilation. |
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Muscarinic receptor antagonists: |
Ipratropium Inhibit ACh-mediatedbronchoconstriction. These drugs not effect histamine leukotriene-mediatedconstriction. |
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Leukotriene receptor antagonists: |
Montelukast inhibit the conversion ofcys-LT2 to cys-LT1, which reduces bronchospasm, plasma exudation and eosinophilrecruitment. |
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Glucocorticoids: |
Beclomethasone, Prednisolone Anti inflammatory steroids |
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Anti-IgE |
Omalizumab binds to IgE and preventscross-linking on the surface of mast cells. |
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Cromoglycate |
These drugs potentially stabilise mast cells andinhibit T-cells. |
