Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
20 Cards in this Set
- Front
- Back
sonota
|
has less day time sedation than ambien and lunesta
|
|
depression mimics
|
high stress levels
increased levels of cortisol -decreases immune function -atrophy of brain structures abnormal circadian rhythm |
|
pimizide can tx
|
OCD and pyschotic disorders
|
|
alpha 1 receptors are
|
Gq
increase intracellular Ca2+ |
|
alpha 2 receptors are
|
Gi
inhibits adenylate cyclase activates K+ channels |
|
beta-1/2/2 receptors
|
Gs
activates adenylate cyclase increases cAMP |
|
alpha-methyl-para-tyrosine(inhibits enzyme involved in catecholoamine synthesis) & resperpine & tetrabenzine (make synaptic vesicles leaky so catcholamines can by broken down by MAOis)
|
produce depression
|
|
reserpine
|
inhibits VMAT (which repackages and stores unmetabolized catecholamines so they can be released back into synapse)
antihypertensive influential in biogenic-amine hypothesis of depression |
|
5HT1A
|
Gi
decreases cAMP |
|
5HT2A/B/C
|
Gq
increases intracellular Ca2+ |
|
5HT4,6,7
|
Gs
increases cAMP |
|
MAO-A
|
Generally, Monoamine Oxidase A (MAOA) prefers to metabolize norepinephrine (NE), serotonin (5-HT), and Dopamine (DA) (and other less clinically relevant chemicals).Monoamine Oxidase B, on the other hand, prefers to metabolize Dopamine (DA) (and other less clinically relevant chemicals).The differences between the substrate selectivity of the two enzymes are utilized clinically when treating specific disorders: Monoamine Oxidase A inhibitors have been used in the treatment of depression, and Monoamine Oxidase B inhibitors are used in the treatment of Parkinson's Disease.
|
|
MAO-B
|
Monoamine Oxidase B, on the other hand, prefers to metabolize Dopamine (DA) (and other less clinically relevant chemicals).The differences between the substrate selectivity of the two enzymes are utilized clinically when treating specific disorders: Monoamine Oxidase A inhibitors have been used in the treatment of depression, and Monoamine Oxidase B inhibitors are used in the treatment of Parkinson's Disease.
|
|
Tyramine effect/cheese effect
|
with MAOis
tyrosine is broken down into tyramine which when not broken down by MAOis displaces NE from VMAT, thus increasing NE in synapse resulting in HT crisis |
|
serotonin syndrome
|
effect of MAOis
prevent breakdown of serotonin increased tryptophan in diet (precursor to serotonin) |
|
5HT4,6,7
|
Gs
increases cAMP |
|
MAO-A
|
Generally, Monoamine Oxidase A (MAOA) prefers to metabolize norepinephrine (NE), serotonin (5-HT), and Dopamine (DA) (and other less clinically relevant chemicals).Monoamine Oxidase B, on the other hand, prefers to metabolize Dopamine (DA) (and other less clinically relevant chemicals).The differences between the substrate selectivity of the two enzymes are utilized clinically when treating specific disorders: Monoamine Oxidase A inhibitors have been used in the treatment of depression, and Monoamine Oxidase B inhibitors are used in the treatment of Parkinson's Disease.
|
|
MAO-B
|
Monoamine Oxidase B, on the other hand, prefers to metabolize Dopamine (DA) (and other less clinically relevant chemicals).The differences between the substrate selectivity of the two enzymes are utilized clinically when treating specific disorders: Monoamine Oxidase A inhibitors have been used in the treatment of depression, and Monoamine Oxidase B inhibitors are used in the treatment of Parkinson's Disease.
|
|
Tyramine effect/cheese effect
|
with MAOis
tyrosine is broken down into tyramine which when not broken down by MAOis displaces NE from VMAT, thus increasing NE in synapse resulting in HT crisis |
|
serotonin syndrome
|
effect of MAOis
prevent breakdown of serotonin increased tryptophan in diet (precursor to serotonin) |