Pharmacology Of Adrenals, Gh And Thyroid

Front 1

A patient with growth hormone deficiency should be treated with:

Back 1

Somatotropin

Front 2

A serious potential side effect of mecasermin is:

Back 2

Hypoglycemia: Take with carbs!

Front 3

The effects of glucocorticoids are mediated by:

Back 3

Nuclear receptors: They're lipid soluble!

Front 4

Which of the following is stimulated by glucocorticoids?
Glycolysis
Gluconeogenesis
Protein Synthesis
Triglyceride synthesis

Back 4

Gluconeogenesis: Glucocorticoids are responsible for the mobilization of energy!

Front 5

Do glucocorticoids have anabolic or catabolic effects on bone?

Back 5

Catabolic

Front 6

Do glucocorticoids have a stimulatory or suppressive effect on the immune system?

Back 6

Suppressive

Front 7

Mineralcorticoids stimulate the reabsorption of:

Back 7

Sodium

Front 8

Two examples of short-acting glucocorticoids are:

Back 8

Hydrocortisone and cortisone

Front 9

Two examples of long acting glucocorticoids are:

Back 9

Betamethasone and dexamethasone

Front 10

This steroid is used in diagnosis of Cushing's Syndrome. It suppresses ACTH and measures cortisol.

Back 10

Dethamethasone.

Front 11

Iatrogenic Cushing's Syndrome is a exogenous form caused by long term administration of what kind of drug?

Back 11

Steroids/glucocorticoids

Front 12

Typically used to treat acute insufficiency/adrenal crisis. This therapy will be coupled with fluids and electrolytes, then a tapered dose of parenteral glucocorticoid over several days, followed by the addition of a mineralcorticoid (which one?)
Finally, the patient will be tapered off to an oral maintenance dose of both.

Back 12

Dexamethasone (preferred because it won't affect serum cortisol levels) or hydrocortisone.
Fludrocortisone is used for sodium retention and increased volume of plasma.

Front 13

This short-acting glucocorticoid is used to treat chronic primary renal insufficiency (Addison's Disease). It is given in 2-3 divided doses to mimic circadian secretion. May be supplemented with a mineralcorticoid (which one?)

Back 13

Hydrocortisone. Supplemented with fludrocortisone.

Front 14

Impaired growth is a frequent complication of long-term _________ use in children, typically for asthma.

Back 14

corticosteroid

Front 15

Antifungal which is also a non-selective inhibitor of steroid synthesis at high doses.
It inhibits CYP3A4 and 2C9, so it has many potential drug interactions.

Back 15

Ketoconazole

Front 16

Selective inhibitor of 11-hydroxylase.
Long term use may result in signs of androgen excess in women.
Also used diagnostically

Back 16

Metyrapone