Pharmacology Nsaids

Front 1

This is the most common Salicylate drug

Back 1

Aspirin

Front 2

These non- narcotic analgesic drugs are a heterogenous group of compounds which share a common mechanism of action and some side effects.

Back 2

NSAIDs
Non-Steroidal Anti-Inflamitory Drugs

Front 3

This is the ability to relieve mild to moderate pain

Back 3

Analgesia

Front 4

This is the ability to decrease the elevated body temperature associated with fever

Back 4

Antipyresis

Front 5

This is the ability to decrease blood clotting by inhibiting platelet aggregation

Back 5

Anticoaggulation

Front 6

This is the ability to decrease inflamation

Back 6

Anti inflamitory

Front 7

The common mechanism of action for all NSAIDs is the inhibition of what?

Back 7

the enzyme cyclooxgenase (COX)

Front 8

Gold salts, chloroquine, D-penicillamine and methotrexate are all drugs used for what condition?

Back 8

Arthritis

Front 9

Colchicine, allopurinol, probenecid and sulfinpyrazone are all drugs used for what condition?

Back 9

Gout

Front 10

This drug is a derivative of salicylic acid.

Back 10

Aspirin

Front 11

This is an enzyme responsible for prostaglandin biosynthesis.

Back 11

Cyclooxygenase (COX)

Front 12

Name the 5 pharmacological actions of aspirin.

Back 12

Analgesia, Anti-inflamatory, Antipyresis, Antiplatelet action and Uric Acid excretion

Front 13

What are these two actions called (collectively)? Prolongation of bleeding time becasue of inhibition of platelet aggregation. Inhibition of platelet thromboxane A2 biosynthesis because of inhibition of COX.

Back 13

Antiplatelet Action

Front 14

What do Antipyresis inhibit?

Back 14

PGE2

Front 15

PGE2 and PGI2 protect lining in the stomach. Aspirin inhibits PGE's. What is the effect?

Back 15

Gastrointestinal problems.

Front 16

What are the Side Effects of Aspirin?

Back 16

Gastrointestinal problems, hyperventilation, mild hepatitis (esp. in pts with arthitis), retention of salt and water, skin rashes, urticaria and angioedema, drug resistant form of asthma

Front 17

Why may one of the side effects of aspirin be a drug resistant form of asthma?

Back 17

Due to the formation of leukotrienes.

Front 18

What are the therapeutic uses for aspirin?

Back 18

Antipyresis, Analgesia, Acute rheumatic fever, rheumatoid arthritis

Front 19

This is used as a cutaneous counterirritation in liniments.

Back 19

Methyl salicylate (NSAID)

Front 20

This is applied topically as a keratolytic agent, in treatment of corns and warts.

Back 20

Salicylic acid

Front 21

The Trade name for Acetaminophen is what?

Back 21

Tylenol

Front 22

This is a weak inhibitor of COX in the peripheral system and potent in the Central Nervous System

Back 22

Acetaminophen

Front 23

This drug has analgesic and antipyretic actions similar to aspirin, but lacks other actions.

Back 23

Acetaminophen

Front 24

This drug may increase the risk of Reye's syndrome in children.

Back 24

Aspirin

Front 25

The principal toxicity associated with acetaminopen overdosage is?

Back 25

fatal hepatic necrosis (death of the liver)

Front 26

What are early symptoms of hepatic damage?

Back 26

nausea, vomiting, diarrhea and abdominal pain

Front 27

Nacetylcyseine (MUCOMYST) is the principal antidotal treatment for what?

Back 27

Acetaminophen overdose

Front 28

This act as an antidotal tx for acetaminophen toxicity by interacting with toxic acestaminophen metabolite to reduce its interaction with liver cells.

Back 28

N-acetylcyteine (MUCOMYST)

Front 29

What are the therapeutic uses for acetaminophen?

Back 29

Analgesia for mild to moderate pain such as headache, myalgia, postpartum pain.

Front 30

This is a metabolic disease in which there is overproduction of purines leading to high levels of uric acid in the blood.

Back 30

Gout

Front 31

This diseases is characterized by intermittent attacks of acute arthritis produced by the deposition of crystals of sodium urate in the synovial tissue of joints and tissues such as the kidney.

Back 31

Gout

Front 32

Gout is a metabolic disease in which there is overproduction of ________ leading to _____________.

Back 32

purines, high levels of uric acid in the blood.

Front 33

Gout is characterized by intermittent attacks of _____________ produced by the deposition of crystals of _________ in the synovial tissue of joints and tissues such as the _________.

Back 33

acute arthritis, sodium urate, kidney.

Front 34

This drug for gout works by inhibiting leukocyte migration into the joint.

Back 34

Colchicine

Front 35

This drug for gout works by inhibiting uric acid synthesis.

Back 35

Allopurinol

Front 36

These drugs for gout works by increasing uric acid secretion

Back 36

Probenecid and Sulfinpyrazone

Front 37

These drugs used for gout act by general ant-inflammatory and analgesic effects

Back 37

NSAIDs

Front 38

Name 5 drugs used for gout.

Back 38

Colchicine, Allopurinol, Probenecid, Sulfinpyrazone, and NSAIDs

Front 39

This drug used for gout interferes with the mobility of neutrophils leading to a decrease of their migration into the inflammed area.

Back 39

Colchicine

Front 40

This drug used for gout does not influence the renal excretion of uric acid or its concentration in blood.

Back 40

Colchicine

Front 41

This drug used for gout does not influence the renal excretion of uric acid or its concentration in blood.

Back 41

Colchicine

Front 42

This drug used for gout does not influence the renal excretion of uric acid or its concentration in blood.

Back 42

Colchicine

Front 43

What are the side effects of colchicine?

Back 43

nausea, vomiting, abdominal pain, aplasic anemia (bone marrow failure), and alopecia (hair loss).

Front 44

What are the therapeutic uses for colchicine?

Back 44

Prophylaxis and acute tx of gout

Front 45

What are the therapeutic uses for colchicine?

Back 45

Prophylaxis and acute tx of gout

Front 46

What are the therapeutic uses for colchicine?

Back 46

Prophylaxis (measures designed to preserve health) and acute tx of gout

Front 47

This drugs therapeutic use is primary hyperuricemia of gout (chronic).

Back 47

Allopurinol (ZYLOPRIM)

Front 48

This drugs side effects include gI disturbances, allergic reactions (skin rashes), acute attacks of gout sometimes occurs in early tx.

Back 48

Allopurinol (ZYLOPRIM)

Front 49

This drug is a purine analog used for chronic gout.

Back 49

Allopurinol (ZYLOPRIM)

Front 50

Allopurinol is used to treat this condition, which is secondary to other conditions (e.g. certain malignancies in which large amounts of purines are produced).

Back 50

Hyperuricemia (excess uric acid in the blood)