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50 Cards in this Set

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This is the most common Salicylate drug
Aspirin
These non- narcotic analgesic drugs are a heterogenous group of compounds which share a common mechanism of action and some side effects.
NSAIDs
Non-Steroidal Anti-Inflamitory Drugs
This is the ability to relieve mild to moderate pain
Analgesia
This is the ability to decrease the elevated body temperature associated with fever
Antipyresis
This is the ability to decrease blood clotting by inhibiting platelet aggregation
Anticoaggulation
This is the ability to decrease inflamation
Anti inflamitory
The common mechanism of action for all NSAIDs is the inhibition of what?
the enzyme cyclooxgenase (COX)
Gold salts, chloroquine, D-penicillamine and methotrexate are all drugs used for what condition?
Arthritis
Colchicine, allopurinol, probenecid and sulfinpyrazone are all drugs used for what condition?
Gout
This drug is a derivative of salicylic acid.
Aspirin
This is an enzyme responsible for prostaglandin biosynthesis.
Cyclooxygenase (COX)
Name the 5 pharmacological actions of aspirin.
Analgesia, Anti-inflamatory, Antipyresis, Antiplatelet action and Uric Acid excretion
What are these two actions called (collectively)? Prolongation of bleeding time becasue of inhibition of platelet aggregation. Inhibition of platelet thromboxane A2 biosynthesis because of inhibition of COX.
Antiplatelet Action
What do Antipyresis inhibit?
PGE2
PGE2 and PGI2 protect lining in the stomach. Aspirin inhibits PGE's. What is the effect?
Gastrointestinal problems.
What are the Side Effects of Aspirin?
Gastrointestinal problems, hyperventilation, mild hepatitis (esp. in pts with arthitis), retention of salt and water, skin rashes, urticaria and angioedema, drug resistant form of asthma
Why may one of the side effects of aspirin be a drug resistant form of asthma?
Due to the formation of leukotrienes.
What are the therapeutic uses for aspirin?
Antipyresis, Analgesia, Acute rheumatic fever, rheumatoid arthritis
This is used as a cutaneous counterirritation in liniments.
Methyl salicylate (NSAID)
This is applied topically as a keratolytic agent, in treatment of corns and warts.
Salicylic acid
The Trade name for Acetaminophen is what?
Tylenol
This is a weak inhibitor of COX in the peripheral system and potent in the Central Nervous System
Acetaminophen
This drug has analgesic and antipyretic actions similar to aspirin, but lacks other actions.
Acetaminophen
This drug may increase the risk of Reye's syndrome in children.
Aspirin
The principal toxicity associated with acetaminopen overdosage is?
fatal hepatic necrosis (death of the liver)
What are early symptoms of hepatic damage?
nausea, vomiting, diarrhea and abdominal pain
Nacetylcyseine (MUCOMYST) is the principal antidotal treatment for what?
Acetaminophen overdose
This act as an antidotal tx for acetaminophen toxicity by interacting with toxic acestaminophen metabolite to reduce its interaction with liver cells.
N-acetylcyteine (MUCOMYST)
What are the therapeutic uses for acetaminophen?
Analgesia for mild to moderate pain such as headache, myalgia, postpartum pain.
This is a metabolic disease in which there is overproduction of purines leading to high levels of uric acid in the blood.
Gout
This diseases is characterized by intermittent attacks of acute arthritis produced by the deposition of crystals of sodium urate in the synovial tissue of joints and tissues such as the kidney.
Gout
Gout is a metabolic disease in which there is overproduction of ________ leading to _____________.
purines, high levels of uric acid in the blood.
Gout is characterized by intermittent attacks of _____________ produced by the deposition of crystals of _________ in the synovial tissue of joints and tissues such as the _________.
acute arthritis, sodium urate, kidney.
This drug for gout works by inhibiting leukocyte migration into the joint.
Colchicine
This drug for gout works by inhibiting uric acid synthesis.
Allopurinol
These drugs for gout works by increasing uric acid secretion
Probenecid and Sulfinpyrazone
These drugs used for gout act by general ant-inflammatory and analgesic effects
NSAIDs
Name 5 drugs used for gout.
Colchicine, Allopurinol, Probenecid, Sulfinpyrazone, and NSAIDs
This drug used for gout interferes with the mobility of neutrophils leading to a decrease of their migration into the inflammed area.
Colchicine
This drug used for gout does not influence the renal excretion of uric acid or its concentration in blood.
Colchicine
This drug used for gout does not influence the renal excretion of uric acid or its concentration in blood.
Colchicine
This drug used for gout does not influence the renal excretion of uric acid or its concentration in blood.
Colchicine
What are the side effects of colchicine?
nausea, vomiting, abdominal pain, aplasic anemia (bone marrow failure), and alopecia (hair loss).
What are the therapeutic uses for colchicine?
Prophylaxis and acute tx of gout
What are the therapeutic uses for colchicine?
Prophylaxis and acute tx of gout
What are the therapeutic uses for colchicine?
Prophylaxis (measures designed to preserve health) and acute tx of gout
This drugs therapeutic use is primary hyperuricemia of gout (chronic).
Allopurinol (ZYLOPRIM)
This drugs side effects include gI disturbances, allergic reactions (skin rashes), acute attacks of gout sometimes occurs in early tx.
Allopurinol (ZYLOPRIM)
This drug is a purine analog used for chronic gout.
Allopurinol (ZYLOPRIM)
Allopurinol is used to treat this condition, which is secondary to other conditions (e.g. certain malignancies in which large amounts of purines are produced).
Hyperuricemia (excess uric acid in the blood)