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27 Cards in this Set

  • Front
  • Back
The study of drugs that alter processes controlled by the nervous system.
Neuropharmacolgy
The process of "conducting" action potential down the "axon" of the neuron.
Axonal Conduction
The process by which information is carried across the gap between the neuron & the postsynaptic cell. Requires the release of NT molecules from the axon terminal & binding of NT molecules to recptors on the postsynaptic cell.
Synaptic Transmission
(Repeat Question)

Most neuropharmacologic agents act by altering synaptic transmission. This is because they are much more what...? (i.e. A char. of an ideal drug)
Selective
Drugs that act by altering this kind of conduction, are not very selective. As a consequence, they will affect conduction in all nerves to which it has access. Local anesthetics are an example of this.
Axonal
The step in synaptic transmission, where in order for this procees to take place, molecules of transmitter must be present in the nerve terminal. This involves the precursor molecules from which the transmitter is "MADE".
Transmitter Synthesis
The step in synaptic transmission where once the transmitter is synthesized, it must be "stored" until the time of it's relase. This takes place in tiny vesicles present in the axon terminal.
Transmitter Storage
The step in synaptic transmission where the "release" of "transmitter" is triggered by the arrival of an action potential at the axon terminal. This initiates a process in which vesicales undergo fusion w/the terminal membrane, causing a release of contents into the synaptic gap.
Transmitter Release
The step in synaptic transmission following release, transmitter molecules diffuse across the synaptic gap & then undergo reversible "binding to receptors" on the postsynaptic cell. This binding initiates a cascade of events that results in altered behavior of the postsynaptic cell.
Receptor Binding
The step in synaptic transmission, where the transmitter can be removed from the synaptic gap by reuptake, enzymatic degradation, & diffusion
Termination of Transmission
The effect on receptor function, equivalent to that produce by natural transmitter, at a particular synapse. (i.e. Activation or Deactivation)
Activation
A drug whose effects "mimic" the effects of a natural transmitter, would be said to do "what" to the receptor activation.
(i.e. Increase or Decrease)
Increase
A drug whose effects were equivalent to "reducing" the amount of natural transmitter for receptor binding, would be said to do what to receptor activation.
(i.e. Increase or Decrease)
Decrease it
(Repeat Question)

A drug that increases transmitter synthesis, will cause an increase in what.
Activation
A drug that decreases transmitter synthesis will cause the transmitter content of vesicles to decline, resulting in reduced transmitter relase, causing what.
(i.e. Increase or Decrease to Transmitter Activation)
Decreased Transmitter
Activation
Conduction of an action potential occurs along the *** of the neuron
Axon
Release of natural transmitters occur from the ******
Axon Terminal
A drug will have no effect, if there's no***** for the specific transmitter.
Receptor
Basic Mech. of transmitter synthesis whereas if a drug ***** transmitter syntheis, it will cause receptor activation to "go up". As a result, storage vesicles will contain transmitters in abnormally high amounts. Hence, when action potential reaches the axon terminal, more transmitter will be released.
Increases
A drug that "does this" to transmitter synthesis, will cause the transmitter content of vesicles to drop, resulting in reduced transmitter release & decreased receptor activation.
Decrease
Basic Mech. of transmitter storage where drugs that interfer with transmitter storage, will cause receptor activation to **** Because distruption of storage depletes vesicles of transmitter content, thereby decreasing amount of transmitter for release.
Decrease
Basic Mech. of Transmitter Release, where drugs that increase receptor activation are known to do this.
(e.g. amphetamine)

(i.e. promote or decrease)
Promote Activation
Basic Mech. of Transmitter release, where drugs that do this to release, will "reduce" receptor activation. (eg. boltulinum toxin).

(Activate or Inhibit)
Inhibit
(Repeat Question)

Basic Mech. of Receptor Binding, where drugs that bind to receptors causes this to happen.
Activation
Basic Mech. of Receptor Binding, where drugs that bind to receptors & block components, thereby do this to receptor activation by the natural transmitter at the site.
Enhance.
Basic Mech. of the Termination of Transmitter Action,where drugs can interfere with termination of transmitter action by two mech. 1)Blockade of transmitter **** and 2)Inhibition of transmitter ****.
Reuptake & Degradation
The more type of receptors that we have to work with, the greater our chances of producing this desired drug effect.
Selectivity