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12 Cards in this Set
- Front
- Back
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What are the postsynaptic effects of ACh
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Excitatory: Involved in arousal, short-term memory, learning and movement
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What are the postsynaptic effects of NE
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Excitatory: Involved in arousal, mood and cardiovascular regulation
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What are the postsynaptic effects of dopamine
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Excitatory: Involved in emotion, reward systems and motor control
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What are the postsynaptic effects of serotonin
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Excitatory/Inhibitory: Feeding behavior, control of body temp., modulation of sensory pathways incl. nociception (stim. of pain nerve sensors), regulation of mood and emotion, sleep/wakefulness
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What are the postsynaptic effects of GABA
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Inhibitory: Inc. Cl- influx into the postsynaptive neuron--> hyperpolarization, Mediates the major inhibitory postsynaptic potentials
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What are the postsynaptic effects of Glycine
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Inhibitory: Inc. Cl- influx
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What are the postsynaptic effects of glutamate
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Excitatory: mediates excitatory Na+ influx into the postsynaptic neuron
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What are the postsynaptic effects of Substance P
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Excitatory: Mediates nociception within the spinal cord
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What are the postsynaptic effects of Met-enkephalin
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Generally Inhibitory: Mediates analgesia as well as other CNS effects
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Mechanism of Parkinsons?
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The combined effects of red. dopamineragic inputs into the neostriatum affect both the direct and indirect pathways in such a away as to allow for enhancement of the inhibitory outputs of the GPm on the thalamic projection nuclei and their target regions in motor cortex, causing hypokinetic mvt disorder
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Mechanism of levadopa action
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- precursor of dopamine that can traverse the BBB
- restores dopaminergic neurotransmission in the corpus striatum by enchancing the synthesis of dopamine in the surviving neurons of the SN - large doses are required because much of it is decarboxylated to dopamine in the periphery --> nausea, vomiting, cardiac arrhythmias, hypotension |
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Mechanism of action: carbidopa
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- dopa decarboxylase inhibitor that does not cross BBB --> increasing availability of levadopa and dec. side effects
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