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25 Cards in this Set

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  • Back
What is the effects and clinical uses of muscarinic agonists called?
parasympathomimetics
What is the effects and clinical uses of muscarinic antagonists called?
parasympatholytics
The effects of M1 and M5 is?
Depolarisation
The effect of M2 and M4 is?
Inhibition
The effect of M3 is?
Stimulation
M4 and M5 are (Neutral/Cardiac/Glandular/CNS/CNS)?
CNS
M1 is (Neural/Cardiac/Glandular/CNS/CNS)?
Neural
M2 is (Neutral/Cardiac/Glandular/CNS/CNS)?
Cardiac
M3 is (Neutral/Cardiac/Glandular/CNS/CNS)?
Glandular
M1 can be found in
CNS, autonomic, ganglia
M2 is found in
atria, SA and AV node
What is the effect of M2 on the heart?
Slowing of heart rate (bradycardia)
Reduced contractility of atria
Slowing of conduction though A-V node
What muscarinic agonist subunit works on the blood vessels?
M3
What is the effect of M3 on glandular secretion?
Increased production of salivary, lacrymal and bronchial secretions
Increased gastric secretion and sweating
What is the effect of M3 on non-vascular smooth muscle
Increased peristaltic activity in gut
Constriction of bronchioles
Bladder – contraction of detrusor muscle and relaxation of sphincter
What is the clinical use of pilocarpine drops
Glaucoma
What is given to cause a stimulation of GIT activity and bladder following surgery
oral bethanecol
cycloplegia (cannot focus for near vision) occurs from muscarinic (agonist/antagonist)
antagonist
What is the effect of muscarinic antagonists of atropine on the CNS?
agitation, confusion, hallucinations and coma
What is the effect muscarinic antagonists of Hyoscine on the CNS?
sedation but high doses produce effects similar to atropine
Hyoscine is clinical use to prevent?
motion sickness
Which muscarinic is used as a bronchiodilator?
Ipratropium in some cases of asthma and chronic bronchitis
Which muscarinic is used in cardiac arrest?
Atropine used to reverse bradycardia
Which muscarinic is used in Parkinsons disease?
Benzatropine used to reduce tremour
빠르다
to be fast/quick