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19 Cards in this Set
- Front
- Back
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alpha antagonists prevent the binding of _____ and ______
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norepi and epi
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does prazosin cause vasodilation or vasoconstriction?
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vasodilation
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Which alpha antagonists are indicated for the treatment of hypertension?
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terazosin, doxazosin, prazosin (mnemonic: Take Down Pressure)
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Which alpha antagonists are indicated in treatment of pheochromocytoma?
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phentolamine, phenoxybenzamine
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Which is reversible, phentolamine or phenoxybenzamine
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phentolamine
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By what mechanism does pheochromocytoma increase BP?
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adrenal tumor causes increased NE/EPI release -> increasing alpha1 activation, constriction of blood vessels, increased BP
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Which alpha anatgonists can be used to treat benign prostatic hyperplasia?
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prazosin, terazosin, doxazosin, tamsulosin, alfuzosin, silodosin
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What is the advantage of using tamsulosin instead of other alpha antagonists in treating BPH?
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tamsulosin has greater affinity for alpha1A than other subtypes -> less side effects
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Which alpha antagonists would be used to treat Raynaud's disease. What is Raynaud's disease?
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Raynaud's = vasospasm in fingers and toes w/ cold exposure. Treat w/ terazosin, doxazosin, prazosin (same as hypertension)
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What can be a profound adverse effect of 1st dose alpha antagonist?
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orthostatic hypotension
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What will happen if you administer propanolol to treat pheochromocytoma without using an alpha blocker in conjunction?
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unopposed vasoconstriction -> increased BP
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which adrenolytics would be used to treat open angle glaucoma?
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topical beta receptor antagonists
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which type of adrenolytics would be used in the treatment of migraines?
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beta receptor antagonists
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What is the mechanism producing essential tremor?
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beta2 receptors on red, slowcontracting skeletal muscle are overstimulated
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What is the main cause of esophageal varices?
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cirrhosis of liver and portal hypertension
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How does propanolol affect exercise?
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causes earlier fatigue
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why are propanolol and metoprolol capable of producing CNS effects?
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they are lipid soluble
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beta2 receptors on the liver trigger what processes when activated?
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increase blood sugar
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What effect does propanolol have on the airways?
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bronchoconstriction
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