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13 Cards in this Set
- Front
- Back
Name three major Macrolides.
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Erythromycin
Clarithtomycin Azithromycin |
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What is the MOA of Macrolides? What about their pharcodynamics?
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They inhibit the 50S ribosomal subunit. They are BACTERIOSTATIC (meaning you have to have a functional immune system for them to work properly)
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What are two mechanisms of resistance to Macrolides?
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Active efflux pump
Altered binding site on ribosomes |
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Generally, how are the Macrolides distributed. Can they be absorbed orally?
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They are large molecules that can't cross the BBB. They like tissues, making them not as good in septicemia.
All of them are bioavailable orally. |
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How are Macrolides eliminated?
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All hepatic (E and C via CYP450, A via bile secretion)
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What are is the spectrum of action for the Macrolides?
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G(+) remember C>E>A: PSSP, Group strep and Viridans, Bacillus, Cor.Dyptharae, Closridium but not C. Diff.
G(-) remember A>C>E: H. Influenzae, Clinda generally good for anerobes abive the diaphragm. Atypicals: P. Jirovicki, Toxoplasmosis |
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What are common side effects of the Macrolides?
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GI (Erythro)
Thrombophlebitis (IV) Ototoxicity |
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Rank the Macrolides on half life.
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Erythro (1.5 hours)
Clarityro (5 hours) Azithro (68 hours) |
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Which Macrolide is best for G(+)?
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Clarithromycin
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Which Macrolide is best for G(-)?
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Azithromycin
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What are Macrolides the DOC for?
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Legionella Pneumophillia
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What Macrolide is safest with other drugs?
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Azithromycin
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What is used as a second line in treating STD's?
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Azithromycin
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