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16 Cards in this Set
- Front
- Back
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What class of drugs cannot be mixed with aminoglycosides?
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B-lactams
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What class of drugs CANNOT be mixed with aminoglycosides?
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B-lactams
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MOA of this class of drugs:
Diffuses through porin channel in outer membrane, binds to 30S ribosome after O2 dependent transport causing termination of translation and stopping synthesis |
aminoglycosides
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Are aminoglycosides active against anaerobes?
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NO
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Aminoglycosides have this effects, causing persistent killing after the drug is gone
*bactericidal |
post-antibiotic effect
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Resistance to this class of drugs:
1. alterations in enzymes 2. efflux drug 3. changes in porins |
aminoglycosides
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This bacteria is intrinsically resistant to aminoglycosides and therefore needs a combo of to stop its growth (gentimycin and penicillin)
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enterococci bacteria
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Which aminoglycoside works best against pseudomonas
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tobramycin
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Why are aminoglycosides not used very often?
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have a risk of nephrotoxicity
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This class of drugs have coverage against gram negative bacteria, space bugs and pseudomonas
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aminoglycosides
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This aminoglycoside is active against tobramycin and gentimycin resistant bacteria
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amikacin
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nephrotoxicity of aminoglycosides takes place in the ______ ______ and is reversible
*binds to megalin causing damage to kidney cells |
proximal tubule
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Ototoxicity associated with aminoglycosides is
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IRREVERSIBLE
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Nephrotoxicity associated wtih aminoglycosides is
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REVERSIBLE
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What is the only role of aminoglycosides used in monotherapy?
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treatment of UTIs
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This class of drugs can be used in:
1. empiric therapy (don't know cause of infection) 2. bacteremia (sepsis patients, fever) 3. pneumonia (nosocomial, hospital acquired) |
aminoglycosides
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