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10 Cards in this Set
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definition of pharmacology
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study of substances that interact with living systems especially by binding to regulatory molecules (receptors) thereby inhibiting or activating body processes.
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definition of a drug
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chemical substances that modify body processes
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definition of chemotherapy
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use of drugs to cure diseases by killing living cells
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definition of toxicology
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study of undesirable effects of drugs on the living system
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administration means....
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drugs must be taken from outside to qualify as a drug
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drug absorption
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process by which administered drugs reaches/ is transferred into systemic circulation from site of administration
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bioavailability....
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fraction of administered drugs reaching the systemic circulation intact
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distribution...
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movement of drugs from central compartment (systemic circulation) to tissues needed
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elimination....
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effective removal of drugs from the body via metabolism and excretion
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factors affecting the rate of GI absorption
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lipid solubility of the drug enhances absorption
increased gastric emptying time enhances absorption by permitting drugs to reach the large surface area of the small intestines for absorption. small particle size of the drug enhances absorption GI motility food e.g. calcium affects absorption of tetracyclines level of ionization: acidic drugs are better absorbed in acidic media |
reduced GI motility may enhance absorption by increasing contact time, also, increased GI motility increases absorption by thorough mixture of intestinal contents.
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